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Table 3 GO terms and KEGG pathways where the candidate genes significantly (p < 0.05) enriched

From: Weighted single-step GWAS identified candidate genes associated with semen traits in a Duroc boar population

Traitsa

Termb

Count

Genes

P-Value

lnNcells

GO:0045639~positive regulation of myeloid cell differentiation

2

CSF3

0.017295

GO:0043401~steroid hormone mediated signaling pathway

2

THRA, NR1D1

0.045478

GO:0005130~granulocyte colony-stimulating factor receptor binding

2

CSF3

0.006326

GO:0030234~enzyme regulator activity

2

PSMD3, MTMR9

0.034316

ssc04919:Thyroid hormone signaling pathway

3

THRA, GATA4, MED24

0.040606

MOT

GO:0006874~cellular calcium ion homeostasis

3

SLC24A4, ATP2C1, SLC30A1

0.010583

GO:0006468~protein phosphorylation

3

ST3GAL1, NEK2, PIK3R4

0.027143

GO:0004672~protein kinase activity

3

NEK2, MAP3K14, PIK3R4

0.041698

PMOT

GO:0006163~purine nucleotide metabolic process

3

NME2, NME1, ADSL

0.000208

GO:0006220~pyrimidine nucleotide metabolic process

2

NME2, NME1

0.026186

GO:0006241~CTP biosynthetic process

2

NME2, NME1

0.029872

GO:0009142~nucleoside triphosphate biosynthetic process

2

NME2, NME1

0.029872

GO:0006228~UTP biosynthetic process

2

NME2, NME1

0.029872

GO:0006183~GTP biosynthetic process

2

NME2, NME1

0.037203

GO:0044822~poly(A) RNA binding

7

TUFM, ATXN2L, UTP18, NME1, NIP7, SNTB2, DNM1

0.04506

ssc01100:Metabolic pathways

10

ST6GALNAC6, NME2, PIP5KL1, PTGES2, ST6GALNAC4, GMDS, NME1, ADSL, DPM2, FDFT1

0.039824

ssc01130:Biosynthesis of antibiotics

4

NME2, NME1, ADSL, FDFT1

0.043421

ABN

GO:0014886~transition between slow and fast fiber

2

GTF2I, GTF2IRD1

0.004569

GO:0007605~sensory perception of sound

3

USH1G, RPL38, SLC9A3R1

0.008744

GO:0001958~endochondral ossification

2

IMPAD1, PEX7

0.035996

  1. a lnNcells Number of sperm cells, MOT Motility, PMOT Progressive motility, ABN Total morphological abnormalities. Within each trait, genomic regions were decreasingly sorted based on the proportion of genetic variance explained
  2. b GO Gene Ontology, KEGG, Kyoto Encyclopedia of Genes and Genomes pathway