Analysis of functional variants in mitochondrial DNA of Finnish athletes

BMC Genomics

Table 2 Mean number of functional variants per subject in haplogroups J and K and other haplogroups

Type of substitution	Haplogroups J and K (n = 22)	Other haplogroups (n = 196)	P value¹
Number of common functional variants
Nonsynonymous	3.64 ± 0.73	0.93 ± 1.30	< 0.000
tRNA	0.68 ± 0.57	0.51 ± 0.65	0.12
rRNA	1.41 ± 0.80	1.41 ± 0.68	0.98
Total	5.73	2.85
Number of rare functional variants
Nonsynonymous	0.68 ± 0.89	0.67 ± 0.89	0.92
tRNA	0	0.15 ± 0.38	0.053
rRNA	0.27 ± 0.46	0.31 ± 0.69	0.71
Total	0.95	1.13

Values are means ± standard deviations. ¹Mann–Whitney test. Samples from all three groups were pooled in order to maximize the number of sequences. Use of Finnish sequences was preferred over the use of sequences from the GenBank in order to avoid introduction of variation caused by population differences

ISSN: 1471-2164