Fig. 3

The effect of two differentially expressed gene comparison methods on the results of Mapman enrichment analysis. Data points are relative Z-values plotted on an x,y-coordinate system, where x corresponds to the Z-value obtained using 0 h as the reference point, and y corresponds to the Z-value calculated using each previous time point in turn as the reference. The vertical and horizontal dotted lines respectively denote x- and y-value significance thresholds (− 1.96 or 1.96). The color of each data point signifies the following: green, |x| and |y| ≤ 1.96 (not significant); red, |x| and/or |y| ≥ 1.96 (significant); blue, |x| and/or |y| ≥ 1.96 and the Z-value is in either the first or third quadrants. (a) (6h_vs_0h) vs (6h_vs_0.75h), (b) (24h_vs_0h) vs (24h_vs_6h), (c) (48h_vs_0h) vs (48h_vs_24h), (d) (144h_vs_0h) vs (144h_vs_48h)