Table 6 Candidate genes for tropical adaptation co-localised with regions of reduced heterozygosity in Djallonke and Sahelian sheep
Sheep | Chr. | Genomic coordinates | Candidate gene | Trait Inference | Reference |
|---|---|---|---|---|---|
DJ | 1 | 85,955,810-86,011,841 | GNAI3 | Melanogenesis (Thermo-tolerance) | Kim et al., 2016 |
DJ | 1 | 188,388,916-188,441,236 | LMLN | Melanogenesis | Kim et al., 2016 |
DJ | 1 | 42,584,598-42,656,778 | IL12RB2 | Immune functions | Roffler et al., 2016 |
DJ | 1 | 168,393,395-168,624,986 | ALCAM | Immune functions | Roffler et al., 2016 |
DJ | 1 | 121,075,675-121,168,117 | SYNJ1 | Phosphatidylinositol dephosphorylation | Roffler et al., 2016 |
Both | 2 | 52,423,842-52,445,175 | NPR2 | Skeletal Morphology and body size | Kijas et al., 2012 |
DJ | 4 | 9,433,282-9,465,962 | KRIT1 | Regulation of endothelial cell proliferation and migration | Roffler et al., 2016 |
DJ | 4 | 85,316,865-85,381,180 | TSPAN12 | Regulation of signal transduction of cell surface receptors | Roffler et al., 2016 |
Both | 5 | 41,256,802-41,272,546 | APC | Immune functions (Tumour suppressor) | Roffler et al., 2016 |
Both | 6 | 36,514,210-36,556,824 | ABCG2 | Urea Metabolism (Homeostasis) | Kijas et al., 2012 |
Djallonke | 6 | 94,584,400-94,605,575 | FGF5 | Regulation of fibroblast growth factor receptor | Kijas et al., 2012 |
Both | 7 | 63,450,344-63,456,226 | BMP4 | Body size and development | Kim et al., 2016 |
DJ | 3 | 204,447,104-204,461,390 | OLR1 | Internalization, degradation of oxidised low density lipoprotein by endothelial cells | Roffler et al., 2016 |
Djallonke | 3 | 108,235,641-108,685,027 | TRHDE | Regulation of appetite and digestion | Kim et al., 2016 |
Djallonke | 3 | 154,219,234-154,397,986 | MSRB3 | Regulation of response to oxidative stress | Kijas et al., 2012 |
Both | 3 | 35,907,955–36,031,445 | ALK | Immune function (Protein phosphorylation) | Kim et al., 2016 |
Both | 3 | 99,472,045-99,509,159 | IL1R1 | Immune function | Kim et al., 2016 |
Djallonke | 9 | 54,817,997-54,825,977 | IL7 | Immune function | Kim et al., 2016 |
Both | 10 | 36,838,524-36,858,872 | ATP12A | Homeostasis (Potassium and Sodium) | Kim et al., 2016 |
Djallonke | 10 | 40,800,056-40,821,770 | PCDH9 | Homophilic cell adhesion | Kim et al., 2016 |
Both | 11 | 36,083,204-36,098,540 | PDK2 | Homeostasis | Kijas et al., 2012 |
Both | 11 | 18,245,395-18,411,418 | NF1 | Homeostasis | Kijas et al., 2012 |
Both | 13 | 78,815,423-78,893,076 | NFATC2 | Immune function | Kijas et al., 2012 |
DJ | 13 | 666,266-1,154,524 | PLCB1 | Thermotolerance | Kim et al., 2016 |
DJ | 15 | 45,551,281-45,552,222 | OR2AG1 | Response to stimulus | Kijas et al., 2012 |
Both | 16 | 38,969,273-39,028,126 | PRLR | Reproduction | Kijas et al., 2012 |
DJ | 17 | 18,131,831-18,226,233 | ELF2 | Regulation of transcription | Kim et al., 2016 |
DJ | 17 | 29,240,707-29,257,289 | PGRMC2 | Reproduction | Kim et al., 2016 |
DJ | 18 | 19,723,286-19,802,578 | ABHD2 | Wound healing | Kijas et al., 2012 |
DJ | 18 | 4,690,980-4,728,935 | ALDH1A3 | Energy, digestive Metabolism | Kim et al., 2016 |
Both | 18 | 38,107,388-38,110,333 | FOXG1 | Regulation of transcription | Kijas et al., 2012 |
Both | 19 | 31,583,789-31,811,540 | MITF | Melanogenesis | Kijas et al., 2012 |
DJ | 19 | 7,255,507-7,331,066 | GLB1 | Cellular metabolism | Kijas et al., 2012 |
DJ | 19 | 33,852,131-34,140,194 | SUCLG2 | Cellular metabolism | Kim et al., 2016 |
Both | 20 | 26,649,266-26,651,191 | HSPA1A | Homeostasis | Â |
Both | 21 | 49,011,232-49,012,130 | IFITM21 | Immune functions | Roffler et al., 2016 |
DJ | 21 | 42,526,284-42,531,851 | BATF2 | Immune functions | Roffler et al., 2016 |