Fig. 1
From: Template-switching artifacts resemble alternative polyadenylation
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12864-019-6199-7/MediaObjects/12864_2019_6199_Fig1_HTML.png)
The mechanisms of internal priming and template switching. (a) Internal priming occurs due to the annealing of a primer to an A-rich region. A-rich regions are typically defined as genomic loci with six or more consecutive As or 12 As out of 20 nucleotides. (b) Template-switching artifacts are produced when the polymerase dislocates during elongation and reinitiates at a homologous sequence of another template