Fig. 2

Lipid profiling of the blood showed ability to alter cholesterol composition in midlife. a Significant difference in total cholesterol plasma concentration at harvest in young runners and between midlife high runners to midlife sedentary mice (young *p = 0.0124, midlife *p = 0.0282). b No significant difference in High Density Lipoprotein (HDL) plasma concentration between runners and sedentary mice. c Significant difference in Low Density Lipoprotein (LDL) plasma concentration between midlife high runners and midlife sedentary mice (*p = 0.0489). d No change in non-fasted glucose plasma concentration across all cohorts. e Significant decrease in in plasma triglyceride between young run and young sedentary concentration (*p = 0.0151). f Significant reduction in Non-Esterified Fatty Acid (NEFA) plasma concentrations between young run and young sedentary cohorts (*p = 0.0374)