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Table 3 Summary of QTL detected by GEMMA for WW in U.S. Gelbvieh beef cattle

From: Genome-wide association and genotype by environment interactions for growth traits in U.S. Gelbvieh cattle

Chr_MbMAF-log10 P-valueSupporting SNPsPositional Candidate GenesLead SNP LocationScientific Precedence [reference]; organism; trait
6_39a0.28918.32107NCAPGExonb[18, 21, 30, 35,36,37,38,39]; Cattle, chicken; stature, calving ease and growth traits association, SimAngus mid-test metabolic weight association, fetal growth, carcass trait association, average daily gain and daily feed intake, muscle mass
14_25a0.39810.692PLAG13’UTR[2, 14, 18, 21, 30, 32,33,34]; Cattle; SimAngus mid-test metabolic weight association, carcass weight, stature, body weight and milk
5_60a0.0468.832LOC527216, LOC788998IntergenicNA
6_36a0.2147.9529CCSER1Intron[14, 60]; Cattle, human; body and carcass weight association, regulator of mitosis
14_26a0.4157.9011IMPAD1, FAM110BIntergenic[30, 32, 34, 40]; Cattle; SimAngus mid-test metabolic weight association, carcass weight association, stature and body weight association, bone and cartilage system
6_42a0.3407.773KCNIP4Intron[39, 41, 42]; Chicken, cattle, human; growth and muscle mass trait association, potassium channel activity
6_38a0.2207.709HERC6, PPM1KIntergenic[49, 58, 59]; Cattle; milk, fat, and protein yield, metabolic processes, feed efficiency association
6_41a0.2386.464LOC782905, SLIT2Intergenic[39, 49,50,51,52,53]; Cattle, chicken, human; milk fat and protein association, organ and muscle weight, development of central nervous system, tumor suppressor activity
6_37a0.3255.975SNCA, GPRIN3Intergenic[61,62,63,64]; Human, goat, equine; neurological regulation, milk and meat associations, tendon tissue association
6_34a0.2955.364LOC100336621, LOC104972717IntergenicNA
  1. a Indicates QTL was detected in EMMAX analysis
  2. b Indicates a predicted nonsynonymous mutation Ile➔Met, exon 9