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Table 2 Spontaneous mutant mice with cleft lip

From: MicroRNA-124-3p suppresses mouse lip mesenchymal cell proliferation through the regulation of genes associated with cleft lip in the mouse

NoGene symbolGene nameReferencePMIDNoteCleft type
1Clf2cleft lip 2[50]7601909Homozygous mutant mice show CL and CP at higher incidence.CLP
2Rpl38ribosomal protein L38[51, 52]10889952; 21529712Heterozygous mutant mice show CL and/or CP.CLO, CLP, or CPO
3Tbx10T-box 10[53, 54]5297683; 15118109Homozygous Tbx10Tg/Tg (gain of function) mice show either unilateral or bilateral CL and CP.CLP
4Wnt9b (aka Clf1)wingless-type MMTV integration site family, member 9B[55]16998816Homozygous null mutant mice show either unilateral or bilateral CL with/without CP.CLO or CLP
5Zeb1zinc finger E-box binding homeobox 1[56, 57]13539273; 10669096Homozygous mutant mice show either unilateral or bilateral and either complete or incomplete CL and CP. Twirler is mouse line name.CLP
6A/HeJNot gene[58]720226010% mice show CL/P.CLO or CLP
7A/JNot gene[58, 59]7202260; 739472010% mice show CL/P.CLO or CLP
8A/WysnNot gene[58]720226020–30% mice show CL/P.CLO or CLP
9CL/FrNot gene[59,60,61]5538410; 7102571; 739472020–40% mice show CL/P. The cleft frequency depends on the colony.CLO or CLP
  1. CLO, cleft lip only; CLP, cleft lip and cleft palate; CPO, cleft palate only