No | Gene symbol | Gene name | Reference | PMID | Note | Cleft type |
---|---|---|---|---|---|---|
1 | Clf2 | cleft lip 2 | [50] | 7601909 | Homozygous mutant mice show CL and CP at higher incidence. | CLP |
2 | Rpl38 | ribosomal protein L38 | 10889952; 21529712 | Heterozygous mutant mice show CL and/or CP. | CLO, CLP, or CPO | |
3 | Tbx10 | T-box 10 | 5297683; 15118109 | Homozygous Tbx10Tg/Tg (gain of function) mice show either unilateral or bilateral CL and CP. | CLP | |
4 | Wnt9b (aka Clf1) | wingless-type MMTV integration site family, member 9B | [55] | 16998816 | Homozygous null mutant mice show either unilateral or bilateral CL with/without CP. | CLO or CLP |
5 | Zeb1 | zinc finger E-box binding homeobox 1 | 13539273; 10669096 | Homozygous mutant mice show either unilateral or bilateral and either complete or incomplete CL and CP. Twirler is mouse line name. | CLP | |
6 | A/HeJ | Not gene | [58] | 7202260 | 10% mice show CL/P. | CLO or CLP |
7 | A/J | Not gene | 7202260; 7394720 | 10% mice show CL/P. | CLO or CLP | |
8 | A/Wysn | Not gene | [58] | 7202260 | 20–30% mice show CL/P. | CLO or CLP |
9 | CL/Fr | Not gene | 5538410; 7102571; 7394720 | 20–40% mice show CL/P. The cleft frequency depends on the colony. | CLO or CLP |