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Table 4 Most significant gene expression associated with RFI and their related metabolic pathway

From: Combining information from genome-wide association and multi-tissue gene expression studies to elucidate factors underlying genetic variation for residual feed intake in Australian Angus cattle

SymbolEffectp-valueDatasetaPathway
NREP-Neuronal Regeneration Related Protein−0.214.66E-06BMMECP2 and Associated Rett Syndrome
NAALADL1- N-Acetylated Alpha-Linked Acidic Dipeptidase Like 10.331.33E-05HB
NCOA4- Nuclear Receptor Coactivator 40.181.49E-05SLPathways in cancer, Thyroid cancer
CD8B- CD8b Molecule0.341.97E-05HBT-Cell Receptor and Co-stimulatory Signaling, Innate Immune System
DHCR7–7-Dehydrocholesterol Reductase−0.292.32E-05BMRegulation of cholesterol biosynthesis by SREBP (SREBF), cholesterol biosynthesis I
ENSBTAG000000395880.393.81E-05HB
SYNE2- Spectrin Repeat Containing Nuclear Envelope Protein 20.114.01E-05BMMeiosis, Ovarian Infertility Genes
OLFML1- Olfactomedin Like 1−0.514.56E-05BM
ANGPTL2- Angiopoietin Like 2−0.275.93E-05BMCommon Cytokine Receptor Gamma-Chain Family Signaling Pathways
ACADSB- Acyl-CoA Dehydrogenase Short/Branched Chain−0.296.29E-05BLFatty acid degradation, Valine, leucine and isoleucine degradation, Metabolic pathways, Fatty acid metabolism
DDIT3- DNA Damage Inducible Transcript 3−0.227.26E-05BMMAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer
TDRP- Testis Development Related Protein−0.451.21E-04HL
CCDC38- Coiled-Coil Domain Containing 380.681.67E-04BL
AIM1- Absent in melanoma 10.151.91E-04BLFatty acid degradation, alpha-Linolenic acid metabolism, Metabolic pathways, Biosynthesis of secondary metabolites, Fatty acid metabolism
PLA2G16- Phospholipase A2 Group XVI0.182.32E-04HLGlycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Metabolic pathways, Ras signaling pathway, Regulation of lipolysis in adipocytes
TMEM135- Transmembrane Protein 135−0.212.50E-04BM
CENPM- Centromere Protein M0.452.82E-04SLChromosome Maintenance, Signaling by Rho GTPases
EIF2A- Eukaryotic Translation Initiation Factor 2A0.162.83E-04BLRNA transport, Protein processing in endoplasmic reticulum
SQLE- Squalene Epoxidas−0.452.84E-04BMSteroid biosynthesis, Metabolic pathways, Biosynthesis of antibiotics
GSTT3- Glutathione S-Transferase Theta 30.272.91E-04BLGlutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Chemical carcinogenesis
HMGCS1–3-Hydroxy-3-Methylglutaryl-CoA Synthase 1−0.242.94E-04BMSynthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism, Terpenoid backbone biosynthesis, Metabolic pathways, Biosynthesis of antibiotics
GHDC- GH3 Domain Containing0.173.59E-04HLInnate Immune System
EIF3H- Eukaryotic Translation Initiation Factor 3 Subunit H0.103.62E-04BLRNA transport, Measles
GPATCH11- G-Patch Domain Containing 110.334.14E-04SL
NET1- Neuroepithelial Cell Transforming 1−0.144.19E-04HLp75 NTR receptor-mediated signaling, fMLP Pathway
BCKDHB- Branched Chain Keto Acid Dehydrogenase E1 Subunit Beta0.104.32E-04SLValine, leucine and isoleucine degradation, Metabolic pathways, Biosynthesis of antibiotics
DNER- Delta/Notch Like EGF Repeat Containing−1.134.33E-04BMSignaling by NOTCH1 and NOTCH2 Activation, Transmission of Signal to the Nucleus
ALDH5A1- Aldehyde Dehydrogenase 5 Family Member A10.144.81E-04BLAlanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways
ROBO2- Roundabout Guidance Receptor 20.495.03E-04BLAxon guidance
GSTM2- Glutathione S-Transferase Mu 20.615.51E-04BLGlutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Chemical carcinogenesis
PRICKLE1-Prickle Planar Cell Polarity Protein 1−0.315.62E-04BLWnt signaling pathway
ENSBTAG000000402810.596.02E-04HB
IFI47- Interferon Gamma Inducible Protein 40.886.02E-04SLTNF signaling pathway
ENSBTAG00000002786−1.106.42E-04SL
RBP1- Retinol Binding Protein 10.557.01E-04HBNicotinate and nicotinamide metabolism, Metabolic pathways
UBE2D2- Ubiquitin Conjugating Enzyme E2 D20.107.21E-04SLUbiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
ENSBTAG00000001489−0.187.24E-04SBPhagosome, Gap junction
GDPGP1- GDP-D-Glucose Phosphorylase 10.327.40E-04HB
ITGB4- Integrin Subunit Beta 40.348.59E-04HLPI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Regulation of actin cytoskeleton, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy
URI1- URI1, Prefoldin Like Chaperone0.199.32E-04SLTranslational Control, Apoptosis and Autophagy
  1. aBM: bulls_muscle, HB: H-heifers_blood, SL: H-steers_blood, BL: A-bulls_liver, HL: H-heifers_liver