Fig. 1

Histone mark signatures of TAD boundaries: a Non-transformed signal patterns, which were higher in the boundary compared to the non-boundary area. ‘0’ is the boundary bin, − 10 and 10 represent the number of bin distance with the center bin. ‘-‘ stands for upstream and ‘+’(ignored) stands for downstream bin. Y axis means each bin’s histone or CTCF modification intensity. b The cosine similarity of different signals between the TAD boundary and non-boundary areas. The inter-type is calculated from inter-category samples and the intra-type is calculated from intra-category samples, respectively