Fig. 1
From: normGAM: an R package to remove systematic biases in genome architecture mapping data
a An illustration of the calculation of fragment biases we newly found. The bins (i.e., A1, A2, A3, B1, and C1) have the same lengths that are equal to the resolution of interest. The plus sign in the table indicates that the bin is detected in the current NP. The negative sign indicates that the bin is not detected in the NP. b An illustration of distance biases between restriction sites in the Hi-C experiments. Different fragment lengths influence ligation efficiency in the Hi-C experiments. c The corresponding fragment length biases in the GAM experiments. Compared with the last NP, the lengths of blue and green fragments in the first two NPs are unevenly detected