Fig. 3

Receiver Operating Characteristic curves for the performance of SMaSH on a fairly low quality RNA-Seq data set. Each curve shows the fraction of true positives as a function of the fraction of false positives. The black solid curves correspond to the full data sets while the colored dashed curves correspond to different degrees of subsampling in order to illustrate how performance depends on read coverage. (a) shows data for all samples while (b) shows data after removal of all comparisons involving one sample that was later excluded from the study due to very low RNA quality. The circles indicate the performance at a p-value cutoff of 0.95