Table 1 Populations of the 1000 Genomes Project included in this study

East Asian (EAS)

Chinese Dai in Xishuangbanna (CDX),

Han Chinese (CHB),

Southern Han Chinese (CHS),

Japanese in Tokyo, Japan (JPT)

African (AFR)

Esan in Nigeria (ESN),

Gambian in Western Division, the Gambia (GWD),

Luhya in Webuye, Kenya (LWK),

Mende in Sierra Leone (MSL),

Yoruba in Ibadan, Nigeria (YRI)

European

(EUR)

Utah residents (CEPH) with European Ancestry (CEU),

Finnish in Finland (FIN),

British in England and Scotland (GBR),

Toscani in Italia (TSI)

Admixed American (AMR)

Colombian in Medellin, Colombia (CLM),

Mexican Ancestry in Los Angeles, California (MXL),

Peruvian in Lima, Peru (PEL),

Puerto Rican in Puerto Rico (PUR)