Fig. 1

a Variants predicted to alter protein functions (variant effect defined as MODERATE, “A non-disruptive variant that might change protein effectiveness”, or HIGH, “The variant is assumed to have disruptive impact in the protein, probably causing protein truncation, loss of function or triggering nonsense mediated decay”, by SnpEff). b Protein sequence altering variants of known cancer genes; GOF: gain of function; LOF: loss of function; matched_GOF: mouse variants matching human GOF variants (exact variants); matched_LOF: mouse variants matching human LOF variants (truncating mutation or missense mutation at the same amino acid); unmatched: mouse variants not reported as known actionable variants in human tumors