Fig. 3

Immune subsets in syngeneic models. a In silico immune cell deconvolution of syngeneic tumor samples. Syngeneic models exhibited various immune cell type infiltrations with major NK cell infiltration predicted in CT26 models. b Comparison of estimated total T-cell fraction of leukocyte in selected mouse syngeneic models and their corresponding human tumors. Human data were downloaded from Gentles et al. [22]. Total T-cell fraction plotted here is the sum of all predicted T-cell subsets including CD4+, CD8+, Treg, and gamma-delta T-cells. c CD3 staining for T-cells, CD11b staining for myeloid cells, and F4/80 staining for macrophage