Fig. 2

Interleukin 22 (IL22)-signaling pathways in different cell types. IL22, produced mainly by immune CD4⁺ T cells, acts upon many different tissue cells, with a key role in the skin, digestive, and respiratory tracts. IL22 acting via its heterodimeric receptor induces activation of many kinases (via MAPs and Jak-STAT pathway) and transcription factors compromised with the expression of pro-inflammatory cytokines. DEGs from inter- (Rpre vs. Spre (1) and Rpost vs. Spost (2)) and intragroup (Rpost vs. Rpre (3) and Spost vs. Spre (4)) comparisons and their respective modulation are shown aside the network objects. Values of expression are represented by colored bars in thermometer-like icons. The red bar represents up-regulation. Network object symbols follow the Metacore® reference guide according to the protein class (https://portal.genego.com/legends/MetaCoreQuickReferenceGuide.pdf), and their names may occasionally differ between tables and the figure due to the MetaBase®