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Table 2 Functional enrichment of non-redundant differentially expressed genes presenting higher variation in the skin of tick-resistant Braford cattle after tick infestation

From: Network analysis uncovers putative genes affecting resistance to tick infestation in Braford cattle skin

CategoryFunction Annotationp-valuez-scoreaGenesb
Behaviorbehavior3.43E-04−2.24CRHR2, CSF2, DDO, DMRTA1, DRD3, GAD2, GAL, GRIA2, GRIK2, GRP, HBA1/HBA2, IL6, MAP6, NPTX2, SLC26A4, SYN1
Cardiovascular System Development and Functiondevelopment of cardiovascular system4.14E-042.19C6, CCR3, CRHR2, CSF2, FOSL1, HBA1/HBA2, HP, IL13RA2, IL20, IL24, IL6, MMP13, OLR1, OPTC, RETN, TNNT2, WNT7A
Cardiovascular System Development and Function, Organismal Developmentangiogenesis3.14E-042.19C6, CCR3, CRHR2, CSF2, FOSL1, HP, IL13RA2, IL20, IL24, IL6, MMP13, OLR1, OPTC, RETN, WNT7A
vasculogenesis1.37E-032.18C6, CCR3, CRHR2, CSF2, IL13RA2, IL20, IL24, IL6, MMP13, OLR1, OPTC, RETN
Cell-To-Cell Signaling and Interactionactivation of cells2.53E-043.38C6, CD79B, CSF2, DRD3, F2RL3, GAD2, GRIK2, IL22, IL24, IL37, IL6, LBP, MMP13, RETN, SOST, TREML2
Cell-To-Cell Signaling and Interaction, Cellular Growth and Proliferationstimulation of cells1.34E-032.04CCL20, CSF2, GAL, GRP, IL22, IL24, IL6
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Traffickingrecruitment of granulocytes1.55E-072.13CCL20, CCR3, COCH, CSF2, GRP, IL22, IL37, IL6, OLR1, TREML2
Cell-To-Cell Signaling and Interaction, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Responserecruitment of neutrophils3.89E-072.21CCL20, COCH, CSF2, GRP, IL22, IL37, IL6, OLR1, TREML2
Cell-To-Cell Signaling and Interaction, Hematological System Development and Functionactivation of blood cells1.39E-042.95C6, CD79B, CSF2, DRD3, F2RL3, GAD2, GRIK2, IL22, IL24, IL37, IL6, LBP, RETN, TREML2
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Responseactivation of leukocytes2.93E-033.09C6, CD79B, CSF2, DRD3, GAD2, IL22, IL24, IL37, IL6, LBP, TREML2
activation of phagocytes2.26E-042.92C6, CSF2, DRD3, IL22, IL24, IL37, IL6, LBP, TREML2
activation of myeloid cells1.20E-042.90C6, CSF2, DRD3, IL22, IL24, IL37, IL6, LBP, TREML2
activation of mononuclear leukocytes1.92E-032.55CD79B, CSF2, DRD3, GAD2, IL22, IL24, IL6, LBP, TREML2
activation of macrophages1.61E-032.39C6, CSF2, DRD3, IL37, IL6, LBP
Cellular Movementmigration of cells7.32E-062.74C6, CCL20, CCR3, COCH, CSF2, DRD3, F2RL3, FAT3, FGFR4, FOSL1, GRIA2, GRP, HP, IGFBP1, IL20, IL22, IL24, IL37, IL6, LBP, MGAT3, MMP13, NPTX2, OLR1, RETN, TREML2, VIL1, WNT7A
cell movement8.23E-062.51C6, CCL20, CCR3, COCH, CSF2, DRD3, F2RL3, FAT3, FGFR4, FOSL1, GRIA2, GRP, HP, IGFBP1, IL13RA2, IL20, IL22, IL24, IL37, IL6, LBP, LRRC6, MGAT3, MMP13, NPTX2, OLR1, RETN, TREML2, VIL1, WNT7A
chemotaxis of cells2.32E-042.17CCL20, CCR3, CSF2, DRD3, GRP, HP, IL20, IL22, IL6, LBP, TREML2
chemotaxis7.34E-052.17CCL20, CCR3, CSF2, DRD3, FOSL1, GRP, HP, IL20, IL22, IL6, LBP, TREML2
Cellular Movement, Hematological System Development and Function, Immune Cell Traffickingcell movement of leukocytes1.82E-042.64C6, CCL20, CCR3, CSF2, DRD3, GRP, HP, IL20, IL22, IL37, IL6, LBP, RETN, TREML2
cell movement of myeloid cells6.05E-052.37C6, CCL20, CCR3, CSF2, GRP, HP, IL20, IL22, IL6, LBP, RETN, TREML2
cell movement of granulocytes1.04E-032.28CCR3, CSF2, GRP, IL20, IL22, IL6, LBP, TREML2
Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Responsecell movement of phagocytes3.28E-042.42C6, CCL20, CCR3, CSF2, GRP, HP, IL20, IL6, LBP, RETN, TREML2
cell movement of neutrophils5.41E-032.41CSF2, GRP, IL20, IL6, LBP, TREML2
chemotaxis of granulocytes5.23E-042.35CCR3, CSF2, GRP, IL20, LBP, TREML2
chemotaxis of myeloid cells1.88E-042.15CCL20, CCR3, CSF2, GRP, HP, IL20, LBP, TREML2
chemotaxis of neutrophils1.62E-032.15CSF2, GRP, IL20, LBP, TREML2
chemotaxis of leukocytes2.79E-052.14CCL20, CCR3, CSF2, GRP, HP, IL20, IL22, IL6, LBP, TREML2
Cellular Movement, Immune Cell Traffickingleukocyte migration6.68E-052.55C6, CCL20, CCR3, COCH, CSF2, DRD3, GRP, HP, IL20, IL22, IL37, IL6, LBP, OLR1, RETN, TREML2
Developmental DisorderHypertrophy5.84E-032.35CSF2, GAL, GRP, IL6, RRAD, SOST, TNNT2, WNT7A
Free Radical Scavengingsynthesis of reactive oxygen species4.37E-042.19CCR3, CSF2, HBA1/HBA2, HP, IL24, IL6, OLR1, PEBP4, RETN, TREML2
Hematological System Development and Function, Tissue Morphologyquantity of blood cells3.84E-032.31C6, CCL20, CCR3, CD79B, CSF2, GAD2, HBA1/HBA2, IGFBP1, IL13RA2, IL22, IL6, IL9R, MMP13, SPTA1
Inflammatory Responseinflammatory response1.38E-052.59C6, CCL20, CCR3, CSF2, DRD3, GAL, GRP, HP, IL20, IL22, IL24, IL37, IL6, LBP, OLR1, TREML2
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistryconcentration of lipid3.37E-042.02CRHR2, CSF2, FGFR4, GAD2, GAL, GRP, HP, IL6, LBP, MGAT3, OLR1, RETN, RRAD, SOST
secretion of lipid3.43E-042.00CSF2, DRD3, GAL, GRP, IL6, RETN
Lipid Metabolism, Small Molecule Biochemistrysynthesis of lipid3.48E-032.40CCR3, CRHR2, CSF2, FGFR4, FOSL1, GAD2, GRP, IL24, IL6, OLR1, RETN
Molecular Transportsecretion of molecule7.96E-052.32ATP4B, CRHR2, CSF2, DRD3, GAL, GRP, IL6, OLR1, RETN, SLC26A4, SYN1, WNT7A
transport of molecule1.18E-032.21ACTN2, ATP4B, ATP6V1G2, CRHR2, CSF2, DRD3, GAL, GRIA2, GRIK2, GRP, HBA1/HBA2, IL6, KCNH4, LBP, OLR1, RETN, SLC26A1, SLC26A4, SYN1, WNT7A
Organismal Developmentformation of vessel4.01E-042.00CRHR2, CSF2, IL6, OLR1, OPTC
  1. aactivation z-score (|z-score| > 2)
  2. bnon-redundant TopDEGs (|log2| FC > 1)