Table 1 Over- and underrepresented terms from a GO enrichment analysis. Cor = Coregonus, Salv = Salvelinus, OGs = orthogroups
GO category | p-value | p-value (Cor + Salv) | # in OGs under selection | # in reference OGs | # in OGs under selection (Cor + Salv) | # in reference OGs (Cor + Salv) |
|---|---|---|---|---|---|---|
Overrepresented GO terms – relaxed selection | ||||||
 PTW/PP1 phosphatase complex | 2.55E-03 | 3.03E-03 | 2 | 0 | 2 | 0 |
 acrosome reaction | 2.55E-03 | 3.03E-03 | 2 | 0 | 2 | 0 |
 integral component of membrane | 3.96E-03 | 1.77E-02 | 21 | 205 | 17 | 163 |
 transcription factor complex | 4.59E-03 | 5.52E-02 | 11 | 78 | 8 | 68 |
 regulation of transcription, DNA-templated | 6.29E-03 | 3.12E-02 | 10 | 70 | 8 | 60 |
 DNA-binding transcription factor activity | 1.22E-02 | 5.98E-02 | 9 | 66 | 7 | 57 |
 regulation of transcription by RNA polymerase II | 1.35E-02 | 2.20E-01 | 4 | 15 | 2 | 14 |
 lipid metabolic process | 1.43E-02 | 8.76E-03 | 2 | 2 | 2 | 1 |
 protein serine/threonine kinase activity | 2.00E-02 | 1.48E-02 | 3 | 9 | 3 | 7 |
 protein tyrosine phosphatase activity | 2.30E-02 | 2.71E-02 | 2 | 3 | 2 | 3 |
 phospholipid catabolic process | 2.30E-02 | 2.71E-02 | 2 | 3 | 2 | 3 |
 tyrosine metabolic process | 3.34E-02 | 3.92E-02 | 2 | 4 | 2 | 4 |
 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 3.34E-02 | 2.71E-02 | 2 | 4 | 2 | 3 |
 serine family amino acid metabolic process | 3.70E-02 | 1.96E-02 | 3 | 12 | 3 | 8 |
 nucleus | 4.42E-02 | 6.75E-02 | 10 | 98 | 9 | 84 |
Overrepresented GO terms – intensified selection | ||||||
 protein deubiquitination | 1.73E-03 | 1.33E-01 | 3 | 4 | 1 | 3 |
 regulation of transcription, DNA-templated | 2.17E-03 | 5.18E-03 | 10 | 81 | 8 | 70 |
 thiol-dependent ubiquitinyl hydrolase activity | 8.36E-03 | 1.02E-01 | 2 | 2 | 1 | 2 |
 DNA binding | 2.48E-02 | 1.68E-02 | 8 | 85 | 7 | 70 |
 steroid hormone receptor activity | 2.71E-02 | 2.29E-02 | 2 | 5 | 2 | 5 |
 acetyl-CoA carboxylase activity | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 acetyl-CoA carboxylase complex | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 Lys48-specific deubiquitinase activity | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 Sin3 complex | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 histone H3-K4 demethylation | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 retinoic acid biosynthetic process | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 NADP-retinol dehydrogenase activity | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 catalase activity | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 obsolete peroxidase reaction | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 response to oxidative stress | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 methane metabolic process | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 hydrogen peroxide catabolic process | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 palmitoyltransferase activity | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 beta1-adrenergic receptor activity | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 adenylate cyclase-activating G protein-coupled receptor signaling pathway | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 positive regulation of heart contraction | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 adrenergic receptor signaling pathway | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 adrenal gland development | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 corticotropin-releasing hormone binding | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 apoptotic signaling pathway | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 regulation of NIK/NF-kappaB signaling | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 iron-sulfur cluster binding | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 actin filament severing | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 dystrophin-associated glycoprotein complex | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 hexosaminidase activity | 3.85E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 hyaluronic acid binding | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
 ribosomal large subunit biogenesis | 3.85E-02 | 3.52E-02 | 1 | 0 | 1 | 0 |
Overrepresented GO terms – diversifying selection | ||||||
 transmembrane transporter activity | 2.28E-02 | 1.19E-02 | 4 | 23 | 4 | 18 |
 transmembrane transport | 2.17E-02 | 1.25E-02 | 6 | 48 | 6 | 41 |
 phospholipid metabolic process | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 regulation of Wnt signaling pathway | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 lipid phosphatase activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 proteolysis | 3.20E-02 | 2.18E-02 | 6 | 53 | 6 | 47 |
 acetyl-CoA carboxylase activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 pyruvate metabolic process | 1.67E-03 | 1.75E-03 | 2 | 0 | 2 | 0 |
 acetyl-CoA carboxylase complex | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 NAD-dependent histone deacetylase activity (H3-K14 specific) | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 histone H3 deacetylation | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 intracellular signal transduction | 1.51E-02 | 4.27E-02 | 4 | 20 | 3 | 16 |
 transforming growth factor beta receptor signaling pathway | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 serine-type endopeptidase activity | 5.27E-03 | 4.56E-03 | 4 | 14 | 4 | 13 |
 cytoskeleton | 4.98E-02 | 4.14E-02 | 2 | 7 | 2 | 6 |
 septin complex | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 complement activation | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 nociceptin receptor activity | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 calcium-mediated signaling | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 glycerolipid metabolic process | 3.98E-02 | 4.14E-02 | 2 | 6 | 2 | 6 |
 kinesin complex | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 kinesin binding | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 lipid catabolic process | 4.88E-03 | 5.10E-03 | 2 | 1 | 2 | 1 |
 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 2.25E-02 | 1.93E-01 | 2 | 4 | 1 | 4 |
 L-ascorbic acid binding | 1.54E-02 | 1.58E-01 | 2 | 3 | 1 | 3 |
 lipoprotein lipase activity | 1.67E-03 | 1.75E-03 | 2 | 0 | 2 | 0 |
 Lys48-specific deubiquitinase activity | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 synapse | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 Sin3 complex | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 sulfate assimilation | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 adenylylsulfate kinase activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 sulfate adenylyltransferase (ATP) activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 glycogen metabolic process | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 antigen processing and presentation of endogenous peptide antigen via MHC class I | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 melatonin receptor activity | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 3-hydroxyisobutyrate dehydrogenase activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 NAD binding | 1.54E-02 | 1.61E-02 | 2 | 3 | 2 | 3 |
 urea transmembrane transporter activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 urea transmembrane transport | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 5-methylcytosine catabolic process | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 methylcytosine dioxygenase activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 DNA demethylation | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 pyrroline-5-carboxylate reductase activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 proline biosynthetic process | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 malate dehydrogenase (decarboxylating) (NAD+) activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 malate metabolic process | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 proteasome regulatory particle assembly | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 beta1-adrenergic receptor activity | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 adenylate cyclase-activating G protein-coupled receptor signaling pathway | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 positive regulation of heart contraction | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 adrenergic receptor signaling pathway | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 small ribosomal subunit | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 10-formyltetrahydrofolate catabolic process | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 formyltetrahydrofolate dehydrogenase activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 hydroxymethyl-, formyl- and related transferase activity | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
 regulation of neuroinflammatory response | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 hexosaminidase activity | 4.11E-02 | 1.00E+ 00 | 1 | 0 | 0 | 0 |
 junctional membrane complex | 4.11E-02 | 4.20E-02 | 1 | 0 | 1 | 0 |
Underrepresented GO terms – diversifying selection | ||||||
 DNA binding | 1.89E-02 | 3.46E-02 | 0 | 93 | 0 | 77 |