Fig. 3
Analysis of WGCNA modules obtained for the hypothalamus and blood differentially expressed genes. Hierarchical clustering of the eigengenes of the modules detected with hypothalamus (a) and blood (b) DEG. Module colors are drawn next to module names, with the number of genes in the modules. Unclustered genes are in the grey module. The boxes on the right indicate whether the module contains over-expressed (LE > CT) genes (red) or under-expressed (LE < CT) genes (blue). Black lines highlight the 2 subsets distinguished by WGCNA for the LE > CT DEG list. c Heatmap of the correlation matrix between the modules eigengenes. Note the negative correlation (pink boxes) between the purple and blue modules (top) and turquoise and red modules (bottom). d Plots of two pairs of module eigengenes from blood DEG. Top: purple vs. blue module from the LE < CT DEG list, bottom: turquoise vs. red module from the LE > CT DEG list. Δdiet is the difference between the LE mean vs. CT mean (symbolized with an empty circle) for each line