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Fig. 5 | BMC Genomics

Fig. 5

From: Chicken adaptive response to low energy diet: main role of the hypothalamic lipid metabolism revealed by a phenotypic and multi-tissue transcriptomic approach

Fig. 5

Proposed mechanism of energy pathways increased in the hypothalamic cells in LE diet. In blue: reactions related to fatty acid β-oxidation (ETFDH, ACADL, ACADS, ECHS1/ECI1, HADH, HADHB, ACAA2), to fatty acids transport through the plasma (FABP4, FABP7, SLC27A1), and the mitochondrial (CPT2, CACT) membrane. In purple: reactions related to TCA cycle (IDH2), to transport of amino-acids (BCKDHA, BCKDHB) and pyruvate (MPC1, MPC2) in the mitochondria, to the integration of amino-acids in the TCA cycle as α-ketoglutarate (GDH1, GPT2) or succinyl-CoA (ALDH6A1, ECHS1, HIBDCH) and of the pyruvate as oxaloacetate (PC). In green: reactions related to oxidative phosphorylation and mitochondrial respiratory chain complex I (MT-ND1, MT-ND2, MT-ND3, MT-ND4, ACAD9, MT-ND4L, MT-ND5, MT-ND6, NDUFA2, NDUFA8, NDUFA10, NDUFB9, NDUFS4, NDUFV3, FOXRED1), complex II (MT-CO1, MT-CO2, MT-CO3, APOPT1, COX14, COX7B, COA5, COA6), complex III (MT-CYB, UQCRB, UQCRQ), complex IV (MT-ATP6, MT-ATP8) and complex V (SDHD, SDHAF2), as well as the entry of ADP in the mitochondria (SLC25A1)

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BMC Genomics

ISSN: 1471-2164

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