Table 2 Top 10 (based on pFDR) KEGG pathways associated with under-expressed (A) and over-expressed DEG (B) in the hypothalamus
Term | # of genes | pFDR |
|---|---|---|
A. Under-expressed genes in LE compared to CT | ||
 Synaptic vesicle cycle | 22 | 7.36 × 10−11 |
 Glutamatergic synapse | 26 | 1.79 × 10−08 |
 Dopaminergic synapse | 26 | 2.37 × 10−07 |
 Axon guidance | 25 | 5.62 × 10−07 |
 Oxytocin signaling pathway | 27 | 2.46 × 10−06 |
 Circadian entrainment | 20 | 2.50 × 10−06 |
 Oocyte meiosis | 21 | 7.03 × 10− 06 |
 Protein processing in endoplasmic reticulum | 26 | 2.04 × 10−05 |
 Nicotine addiction | 12 | 2.04 × 10−05 |
 GABAergic synapse | 17 | 5.18 × 10− 05 |
B. Over-expressed genes in LE compared to CT | ||
 Ribosome | 83 | 1.03 × 10−67 |
 Metabolic pathways | 166 | 2.57 × 10−25 |
 Oxidative phosphorylation | 46 | 3.26 × 10−22 |
 Glycine, serine and threonine metabolism | 15 | 7.73 × 10−08 |
 Fatty acid metabolism | 15 | 1.81 × 10−06 |
 Fatty acid degradation | 14 | 2.52 × 10−06 |
 Valine, leucine and isoleucine degradation | 14 | 3.18 × 10−06 |
 PPAR signaling pathway | 16 | 3.65 × 10−05 |
 Carbon metabolism | 19 | 1.54 × 10−04 |
 Alanine, aspartate and glutamate metabolism | 10 | 4.70 × 10−04 |