Fig. 8
From: Investigating host-bacterial interactions among enteric pathogens
Role of UDP-glucose in innate immune response and the probable UshA mediated mechanism of evading host defense by invading enteric pathogens. Human epithelial cells, in response to bacterial infection, release UDP-glucose. The released UDP-glucose acts as a signal to trigger innate immune responses. UshA, a UDP-glucose hydrolase can degrade the signaling molecule (UDP-glucose), and possibly acts as a virulence factor by abrogating the host defenses