Skip to main content

Table 3 Number of differentially expressed gene (DEG) associated with immune-related KEGG pathways determined in both head kidney and liver for peptidoglycan (PGN) and poly I:C treated fish, assessed by comparison of against PBS-treated fish in each same group. Total number of DEGs of each genotype were different from the sum of values because some genes have multi-functional characteristics by KEGG pathway analysis

From: Effect of growth rate on transcriptomic responses to immune stimulation in wild-type, domesticated, and GH-transgenic coho salmon

Immune-related KEGG pathway PGN-treated / PBS-treated Poly I:C-treated / PBS-treated
Full name Abbreviation Head kidney Liver TotalDEG Head kidney Liver Total DEG
D TR TF W D TR TF W   D TR TF W D TR TF W  
Antigen processing and presentation APP       2   2 2   2    1     3
Complement and coagulation cascades CCC   1     1   1 2   1        1
Cytosolic DNA-sensing pathway CDs          0   1        1
C-type lectin receptor signaling pathway CLRs   1      1   2   1     1    1
Chemokine signaling pathway Cs   2       1 2   3     1   1 4
Fc gamma R-mediated phagocytosis FGRP   2 1 1   1    3          0
Intestinal immune network for IgA production IINIP          0   1        1
IL-17 signaling pathway ILs   1     2 1 1 2      1    1 2
Leukocyte trans-endothelial migration LTM   2   1 1 3   1 3          0
NOD-like receptor signaling pathway NRs     1      1   3    1 2   1 4
Platelet activation PA       1    1          0
RIG-I-like receptor signaling pathway RRs          0   2     1   3 3
Th17 cell differentiation TCD          0   1    1 1   1 3
Toll and Imd signaling pathway TIs       1 1 2 2          0
Toll-like receptor signaling pathway TRs       2   2 2   2     1    2
Th1 and Th2 cell differentiation TTCD          0   1     1    1
Total   9 1 3 1 13 3 10 21   18    4 8   7 15
Average fold change   3.0 3.3 6.9 10.9 15.8 5.5 2.8 9.0   12.8    7.3 7.9   4.2 16.0
  1. PBS phosphate-buffered saline, PGN peptidoglycan, Poly I:C polyinosinic-polycytidylic acid. W, non-transgenic (wild-type) coho salmon on a full satiation ration, TF GH transgenic coho salmon on a full satiation ration, TR GH transgenic coho salmon on restricted ration equal to that consumed by W, D domesticated coho salmon on a full satiation ration