Fig. 3

Gene ontology (GO) classification and kyoto encyclopedia of genes and genomes (KEGG) analysis of target genes of the differentialy expressed miRNAs. a GO annotation of 16 candidate target genes. The x-axis indicates the GO category; the right y-axis indicates the number of target genes in a category; the left y-axis indicates the percentage of target genes annotated with a specific term under the main category. b KEGG pathway enrichment scatter plot of 17 candidate target genes. Each graph represents a KEGG pathway and the pathway name is shown in the right graph. The abscissa is the enrichment factor, indicating the proportion of the number of differentially expressed miRNA target genes annotated to a certain pathway in the total number of genes annotated to this pathway. The larger the enrichment factor, the more significant the level of enrichment of differentially expressed miRNA target genes in this pathway. The ordinate is -log10 (Q value), where Q is the P value after correction by the multiple hypothesis test. Thus, the larger the ordinate, the more reliable the significance of the enrichment of the differentially expressed miRNA target gene in this pathway. c KEGG classification map of the target genes of the differentialy expressed miRNAs. The ordinate is the KEGG metabolic pathway; the abscissa is the number of genes annotated to the pathway and their proportion to the total number of genes annotated