Table 2 Thirty-six out of the 397 highly concordant orthologous genes with an epigenetic function based on the EpiFactors database. Genes are sorted by decreasing abundance

130816

DNMT1

DNA methyltransferase 1

DNA modification

dhC

132646

PCNA

Proliferating cell nuclear antigen

Chromatin remodeling

H2A, H2B

113558

SKP1

S-phase kinase associated protein 1

Histone modification write cofactor

N/A

120533

ENY2

ENY2, transcription and export complex 2 subunit

Histone modification erase cofactor

N/A

162961

DPY30

Dpy-30, histone methyltransferase complex regulatory subunit

Histone modification write cofactor

N/A

187109

NAP1L1

Nucleosome assembly protein 1 like

Histone chaperone

N/A

185787

MORF4L1

Mortality factor 4 like 1

Histone modification read

H4

132780

NASP

Nuclear autoantigenic sperm protein

Chromatin remodeling

H1

276043

UHRF1

Ubiquitin like with PHD and ring finger domains 1

Histone modification read, Histone modification write cofactor

H3K9me3, H3R2, H3, mCG

115289

PCGF1

Polycomb group ring finger 1

Polycomb group (PcG) protein

N/A

075914

EXOSC7

Exosome component 7

Scaffold protein, RNA modification

N/A

075624

ACTB

Actin beta

Chromatin remodeling cofactor

N/A

166164

BRD7

Bromodomain containing 7

Histone modification read

H3K9ac, H3K14ac, H3K8ac

166913

YWHAB

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

Histone modification erase cofactor

N/A

149554

CHEK1

Checkpoint kinase 1

Histone modification write

H3.1

136938

ANP32B

Acidic nuclear phosphoprotein 32 family member B

Histone chaperone

H3, H4

134058

CDK7

Cyclin dependent kinase 7

Histone modification write

H1

136518

ACTL6A

Actin like 6A

Chromatin remodeling cofactor

N/A

055130

CUL1

Cullin 1

Chromatin remodeling cofactor

H3K9me3, H3K36me3, H1.4K26me3

100749

VRK1

Vaccinia related kinase 1

Histone modification write

H3S10, H3T3

163875

MEAF6

MYST/Esa1 associated factor 6

Histone modification write cofactor

H2A, H3K14, H4K5, H4K8, H4K12

057935

MTA3

Metastasis associated 1 family member 3

Chromatin remodeling cofactor

N/A

123737

EXOSC9

Exosome component 9

Scaffold protein, RNA modification

N/A

100387

RBX1

Ring-box 1

Histone modification write cofactor

H3, H4

151332

MBIP

MAP 3 K12 binding inhibitory protein 1

Histone modification write cofactor

N/A

197323

TRIM33

Tripartite motif containing 33

Histone modification read

H3K9me3, H3K18ac

119969

HELLS

Helicase, lymphoid specific

Chromatin remodeling

N/A

169375

SIN3A

SIN3 transcription regulator family member A

Histone modification erase cofactor, TF

DNA motif

133884

DPF2

Double PHD fingers 2

Chromatin remodeling

N/A

258315

C17orf49

Chromosome 17 open reading frame 49

Histone modification read

H3K4me3

108468

CBX1

Chromobox 1

Histone modification read

H3K9me3, H3K27me3

177889

UBE2N

Ubiquitin conjugating enzyme E2 N

Histone modification write

H2AX

186591

UBE2H

Ubiquitin conjugating enzyme E2 H

Histone modification write

H2A, H2B

139620

KANSL2

KAT8 regulatory NSL complex subunit 2

Histone modification write cofactor

H5

100823

APEX1

Apurinic/apyrimidinic endodeoxyribonuclease 1

DNA modification cofactor

N/A

167986

DDB1

Damage specific DNA binding protein 1

Histone modification write

H2A