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Table 1 Classification of gene clusters (ID1–54) corresponding to the dendrogram in Fig. 4

From: Divergence of metabolites in three phylogenetically close Monascus species (M. pilosus, M. ruber, and M. purpureus) based on secondary metabolite biosynthetic gene clusters

ID Type of GCs Pi Ru Pu Secondary metabolic pathways detected in DNA sequence homology ATP-binding cassettes Identity level
1 t1pks 1 4 – Narbonolide/10-deoxymethynolide (pikAI – AIV), Phthiocerol/phenolphthionocerol (ppsA - E) – **
2 t1pks 2 – – Phthiocerol/phenolphthionocerol (ppsA - E) – –
3 t1pks 18 19 7 Azaphilone*, Lovastatin (LOVB, LOVF), Narbonolide/10-deoxymethynolide (pikAI – AIV), Phthiocerol/phenolphthionocerol (ppsA - E) – –
4 t1pks 22 – – – – *
5 t1pks 23 48 17 Lovastatin (LOVB, LOVF), Narbonolide/10-deoxymethynolide (pikAI – AIV), Phthiocerol/phenolphthionocerol (ppsA - E) – *
6 t1pks 19 43 – Monacolin K*, Compactin, Lovastatin (LOVA, LOVB) – *
7 t1pks – – 8 Citrinin*, Narbonolide/10-deoxymethynolide (pikAI–AIV), Phthiocerol/phenolphthionocerol (ppsA-C, E) – *
8 t1pks 9 – 10 Byssochlamic acid*, Narbonolide/10-deoxymethynolide (pikAI–AIV), Phthiocerol/phenolphthionocerol (ppsA-C, E) – *
9 nrps 4 10 19 Neosartoricin*, Fengycin (fenA–E), Surfacin (srfAA-AC) – **
10 nrps 13 30 20 Brevianamide F (FTMA) ABCB **
11 nrps 7 2 – Fengycin (fenA-E), Surfacin (srfAA-AC) ABCC **
12 nrps 11 23 2 Fengycin (fenA-D) ABCC **
13 nrps 5 22 12 Fengycin (fenA-D) – *
14 nrps 24 21 – Fengycin (ppsA-D), surfacing (srfAA-AC) ABCB *
15 nrps 3 41 – Fengycin (fenA–D) – *
16 nrps – – 9 Fengycin (fenB, D), Ferricrocin (SIDC, SIDD) – –
17 t1pks-nrps 8 40 5 NG-391*, Fengycin (fenA–E), Surfacin (surAA-AC) ABCC **
18 t1pks-nrps 14 27 14 Gramicidin (grsA-B), Fengycin (fenA–E), Surfacin (surAA-AC) – *
19 t1pks-nrps 20 13 3 Lovastatin (LOVB, LOVF), Fengycin (fenA-E), Surfactin (srfAA-AC) ABCB *
ID Type of GCs Pi Ru Pu Secondary metabolic pathways detected in DNA sequence homology ATP-binding cassettes Identity level
20 terpene 12 24 11 Fernesyl-diphosphate (FDFT1) – **
21 terpene 17 12 13 Lupeol (LUP1,2,4,5), Arabidiol (PEN1), Tinucalladienol (PEN3), seco-amyrin (PEN6) – *
22 terpene – – 15 – – –
23 others 15 42 18 Fengycin (fenA, C, E), Surfacin (srfAA-AB) ABCF **
24 others 6 32 6 Kinesin (KIDFC1–3) – *
25 others 10 5 16 Abscisic aldehyde (AAO1–4), Fengycin (fenA, B, E), Surfactin (srfAA, AB) ABCB *
26 others 16 33 4 Histidinol (hisD, IE) – *
27 others 21 28 1 – – *
28 cf-putative – 1 – – – –
29 cf-putative – 3 – Palmitin (ZDHHC) – –
30 cf-putative – 6 – Palmitin (ZDHHC4) – –
31 cf-putative – 7 – – – –
32 cf-putative – 8 – – – –
33 cf-putative – 9 – – – –
34 cf-putative – 11 – – – –
35 cf-putative – 14 – Serine, Threonine (PP1C, 2C, 4C, 6C) – –
36 cf-putative – 15 – – ABCG2 –
37 cf-putative – 16 – – – –
38 cf-putative – 17 – – – –
39 cf-putative – 18 – Mannan (ANPI, MNN9) – –
40 cf-putative – 20 – – – –
41 cf-putative – 25 – – – –
42 cf-putative – 29 – – – –
43 cf-putative – 31 – – – –
44 cf-putative – 34 – – – –
45 cf-putative – 36 – – – –
ID Type of GCs Pi Ru Pu Secondary metabolic pathways detected in DNA sequence homology ATP-binding cassettes Identity level
46 cf-putative – 37 – – – –
47 cf-putative – 38 – – – –
48 cf-putative – 39 – Lovastatin (LOVB-G), Phthiocerol/Phenolphthiocerol (ppsA,C) – –
49 cf-putative – 44 – – – –
50 cf-putative – 45 – – – –
51 cf-putative – 46 – – – –
52 cf-putative – 47 – – – –
53 cf_fatty_acid – 26 – – – –
54 cf_fatty_acid – 35 – Fatty acid (FAS1,2) – –
  1. The type of GCs was determined using antiSMASH software. Pi, Ru, and Pu represent the cluster ID in Fig. 4. Identical gene organization is denoted by red numbers. The secondary metabolic pathways represent the secondary metabolite information based on DNA sequence homology. Type of ATP-binding cassettes detected in individual groups is represented as ATP-binding cassettes. Gene-cluster groups with both identical gene organization and high DNA sequence similarity are denoted by ‘**’ and groups with only high DNA sequence similarity are denoted by ‘*’. Two-letter abbreviations use used for the Venn diagrams: Pi, M. pilosus NBRC 4520; Ru, M. ruber NBRC 4483; Pu, M. purpureus NBRC 4478
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BMC Genomics

ISSN: 1471-2164

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