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Table 3 Saos-2 Telomere lengths

From: Single-molecule analysis of subtelomeres and telomeres in Alternative Lengthening of Telomeres (ALT) cells

 

End telomere

End telomere loss

Recombined Ends with ITS

ITS Loss

(TTAGGG) n < 500 bp

% Recombinant Subtelomere Molecules

% of total analyzed for subtelomere

Longest Telomere

Chr-parm

Mean Length (kb) ± Std (# telomeres)

(# molecules)

Mean Length (kb) ± Std (# telomeres)

(# molecules)

# molecules (# end, # ITS)

Length (kb)

1p

4.8 ± 8.6 (14)

3

1.6 ± 1.8 (23)

3

5 (3,2)

62

30.5

2p

4.5 ± 3.5 (31)

1

nd

0

1 (1,0)

0

11.0

3p

7.5 ± 5.5 (30)

1

nd

0

1 (1,0)

0

25.5

4p

3.3 ± 2.7 (24)

2

nd

0

0 (0,0)

0

9.9

5p

5.9 ± 5.6 (14)

0

2.6 ± 1.6 (7)

0

0 (0,0)

41

18.3

6p

7.7 ± 7.6 (10)

1

3.1 ± 0 (1)

0

0 (0,0)

10

18.4

7p

N/A

N/A

N/A

N/A

N/A

N/A

N/A

8p

N/A

N/A

N/A

N/A

N/A

N/A

N/A

9p

4.7 ± 4.2 (17)

1

nd

0

0 (0,0)

0

13.6

10p

2.1 ± 1.7 (19)

2

nd

0

2 (2,0)

0

6.7

11p

5.3 ± 5.1 (7)

0

5.0 ± 5.8 (3)

0

0 (0,0)

30

11.8

12p

6.5 ± 4.7 (26)

2

nd

0

0 (0,0)

0

15

13p

nr

 

nr

    

14p

nr

 

nr

    

15p

nr

 

nr

    

16p

INP

 

INP

    

17p

INP

 

INP

    

18p

3.6 ± 3.0 (31)

0

1.1 ± 0 (1)

0

2 (2,0)

3

13.1

19p

4.1 ± 4.0 (30)

1

5.1 ± 3.9 (5)

0

4 (4,0)

 

13.2

20p

2.0 ± 1.5 (20)

1

nd

0

3 (3,0)

0

4.9

21p

nr

 

nr

    

22p

nr

 

nr

    

Xp/Yp

nr

 

nr

    

Chr-qarm

 1q

4.1 ± 4.6 (25)

3

2.9 ± 2.0 (4)

0

2 (2,0)

3

12.9

 2q

N/A

N/A

N/A

N/A

N/A

N/A

N/A

 3q

0 ± 0 (1)

1

0.9 ± 0.6 (7)

0

3 (0,3)

88

1.8

 4q

0.7 ± 0.9 (3)

1

nd

0

1 (1,0)

0

1.7

 5q

5.7 ± 3.6 (27)

0

1.5 ± 0 (1)

0

0 (0,0)

4

12.4

 6q

8.9 ± 10.0 (27)

2

14.5 ± 3.7 (5)

0

2 (2,0)

16

50

 7q

1.9 ± 1.4 (27)

0

1.3 ± 0 (1)

0

2 (2,0)

4

6.1

 8q

1.1 ± 0.7 (15)

1

1.4 ± 0.9 (18)

0

3 (3,0)

55

3.4

 9q

N/A

N/A

N/A

N/A

N/A

N/A

N/A

 10q

3.0 ± 3.9 (30)

0

0.7 ± 0.9 (2)

0

2 (1,1)

 

15.9

 11q

N/A

N/A

N/A

N/A

N/A

N/A

N/A

 12q

N/A

N/A

N/A

N/A

N/A

N/A

N/A

 13q

6.4 ± 6.2 (30)

1

7.6 ± 6.2 (5)

0

2 (2,0)

14

23.3

 14q

2.3 ± 2.7 (26)

1

nd

0

5 (5,0)

0

6.3

 15q

N/A

N/A

N/A

N/A

N/A

N/A

N/A

 16q

6.8 ± 17.7 (13)

2

nd

0

0 (0,0)

0

62.8

 17q

1.6 ± 1.9 (10)

2

1.7 ± 2.5 (16)

0

4 (0,4)

62

10.1

 18q

2.6 ± 3.4 (28)

4

nd

0

5 (5,0)

0

13.1

 19q

5.1 ± 5.4 (31)

12

2.6 ± 2.3 (2)

0

1 (1,0)

 

20.5

 20q

N/A

N/A

N/A

N/A

N/A

N/A

N/A

 21q

1.3 ± 0.6 (6)

1

1.9 ± 0.7 (22)

0

1 (1,0)

79

3.6

 22q

INP

 

INP

    

Xq/Yq

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Total

548

46

118

3

52 (42,10)

19

 
  1. N/A no data, not enough molecules to measure the telomere length
  2. INP inverted nick pair (INP) sites
  3. nr no reference sequences or significant gaps in the reference sequence
  4. nd Not detected
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