Fig. 2

TMA-synthesis of GM is increased in AF patients. a The relative abundance of KEGG orthologs and modules associated with TMA-synthesis process in CTR and AF. OR score > 2 (enriched in AF, red), 0.5 < OR score < 2 (not significant, grey), and OR score < 0.5 (enriched in CTR). b The box plot shows significantly enriched abundance of 13 KEGG orthologs and modules in the gut of AF patients. Boxes stand for interquartile ranges, with lines representing medians and circles for outliers. c Relative abundance of the 13 KEGG orthologs and modules across CTR and AF groups, including PAF, Pers< 12 m, and Pers> 12 m. Statistical difference was defined at the standard of q-value < 0.05 by Wilcoxon rank-sum test, with P-value corrected into q-value using the Benjamini-Hochberg method. Abundance profiles after transformation into Z scores through subtracting the mean abundance and divided by the standard deviation. Z scores colored in blue (negative) or red (positive) indicated row abundance less or more than the average, respectively. KEGG orthologs/modules at q-value < 0.01 are shown as an asterisk colored in dark green, q-value < 0.05 with an asterisk colored in light green, and q-value ≥0.05 with an asterisk colored in gray