Fig. 2
From: Circular DNA intermediates in the generation of large human segmental duplications
Formation and integration of the circular intermediates, shown as a general example for the generation of cSDP1. A Opening and integration of cSDP1 circular intermediate: (Top) ancestral cSDP1 showing sequence fragments flanking the A and D ends of the duplication; (Middle) putative circular intermediate, showing a 56 bp close up of sequence flanking the breaking point, and acceptor sequence in the common ancestor orangutans and gorillas; (Bottom) derivative cSDP1 showing sequence fragments flanking the β-C and B-α junctions. B Circular intermediate closing junction. Alignment of the sequences flanking the ends of the ancestral sequence A and D and the AD junction in the derivative sequence. Deleted and inserted base pairs are underlined and shown in italic and orange bold letters respectively. Sequence outside the cSDP is depicted in small letters