Fig. 5

Multiple omics integrative analysis for the four kinds omics data obtained in this study. a. Sample scatterplot made with plotDiablo, displaying the first component in the four data set (upper diagonal plot) and the Pearson correlation between each component (lower diagonal plot). b. Clustered image map (Euclidean distance, Complete linkage) of the multi omics signature. Information from the eight sheep in the study are represented by rows, whereas selected features from each of the four omics datasets are represented by columns (according to the color code line below the cladogram). c. Circos plot showing positive (brown lines) and negative (black lines) correlations (r > 0.9) between selected features from each dataset (feature names appear in each quadrant). d. Potential cross talk between multiple molecular layers. Red line, positive correlation; green line, negative correlation; blue arrow