Fig. 4
Overall gene expression and number of differentially expressed genes in KEGG pathways relating to metabolism and cardiac muscle contraction. For the skeletal muscle (top row), comparisons for aerobic (TCA-cycle and oxidative phosphorylation) and anaerobic (glycolysis/ gluconeogenesis) metabolism are given. For the cardiac comparisons (bottom row) comparisons for cardiac contraction, calcium cycling, and adregenic signalling in cardiomyocytes for the cardiac comparisons are also given. The five pairwise comparisons are separated by vertical dashed lines, with the three between-muscle comparisons on the top row. Significance in t-tests of overall expression between each pair of tissues is indicated with a * under the bar representing the tissue with elevated expression, with the Benjamini-Hochberg corrected p-value given below. Bars are coloured red and blue, as indicated to represent each of the two tissues in each comparison. Standard errors are not plotted, but all are below 1% overall gene expression. The bracket above each pair of bars signifies which metabolic pathway it corresponds to with the following abbreviations: Gl – glycolysis / gluconeogenesis; OP – oxidative phosphorylation; TCA – TCA/ citrate cycle; CC – cardiac contraction; Ca2+ − calcium signalling; AS – adregenic signalling in cardiomyocytes