Table 2 Gene Ontology (GO) terms enriched and KEGG pathways upregulated relating to aerobic or anaerobic metabolism and calcium cycling in each tissue. For full list and p values, see Table S2. None means no GO term was enriched and no KEGG pathways upregulated
Tissue | Compared against | Metabolic or calcium cycling upregulated GO terms | |
|---|---|---|---|
Pathway | GO terms and KEGG pathways upregulated for each category | ||
White muscle | Red muscle | Anaerobic metabolism | Molecular Function: 1 (6-phosphofructokinase activity) |
Biological Process: 6 (Glycogen metabolic process, Glycolytic process, Fructose 6-phosphate metabolic process, Gluconeogenesis, Carbohydrate metabolic process, Glycolytic process through fructose-6-phosphate) | |||
KEGG Pathway: 1 (Glycolysis/ gluconeogenesis) | |||
Calcium cycling | Cellular Component: 1 (Endoplasmic reticulum membrane) | ||
Biological Process: 2 (Release of sequestered calcium ion into cytosol, Calcium ion homeostasis) | |||
KEGG Pathway: 1 (Calcium signalling pathway) | |||
Red muscle | White muscle | Aerobic metabolism | Cellular Component: 3 (Mitochondrial matrix, Proton-transporting ATP synthase complex, coupling factor f(o), Mitochondrial membrane) |
Molecular Function: 4 (CoA-ligase activity, Cytochrome-c oxidase activity, NAD binding, Isocitrate dehydrogenase activity) | |||
Biological Process: 9 (Tricarboxylic acid cycle, ATP synthesis coupled proton transport, ATP hydrolysis coupled cation transmembrane transport, Mitochondrial ATP synthesis coupled electron transport, Electron transport chain, Acyl-CoA metabolic process, Acetyl-CoA biosynthetic process, ATP synthesis coupled electron transport, Mitochondrial transport) | |||
KEGG Pathway: 2 (TCA cycle, Oxidative phosphorylation) | |||
Calcium cycling | Molecular Function: 1 (Calcium-transporting ATPase activity) | ||
Deep white muscle | Superficial white muscle | None | None |
Superficial white muscle | Deep white muscle | Calcium cycling | Molecular Function: 1 (Calcium-release channel activity) |
Deep red muscle | Superficial red muscle | 0 | None |
Superficial red muscle | Deep red muscle | Calcium cycling | Molecular Function: 1 (Calcium-release channel activity) |
KEGG Pathway: 1 (Calcium signalling pathway) | |||
Atrium | Ventricle | Anaerobic metabolism | Molecular Function: 1 (6-phosphofructokinase activity) |
Biological Process: 2 (Glycolytic process through fructose-6-phosphate, Fructose 6-phosphate metabolic process) | |||
Calcium cycling | Molecular Function: 2 (Calcium ion binding, Calcium-transporting ATPase activity) | ||
Biological Process: 2 (Calcium ion transmembrane transport, Regulation of calcium ion transmembrane transporter activity) | |||
Ventricle | Atrium | Aerobic metabolism | Cellular Component: 4 (Respiratory chain complex, Inner mitochondrial membrane protein complex, Mitochondrial respiratory chain, Mitochondrial membrane) |
Molecular Function: 4 (Proton-transporting ATP synthase activity, rotational mechanism, Electron transfer activity, CoA-ligase activity, Acid-thiol ligase activity) | |||
Biological Process: 2 (Fatty acid beta-oxidation, ATP synthesis coupled proton transport) | |||
KEGG Pathway: (TCA cycle, oxidative phosphorylation) | |||
Anaerobic metabolism (3) | Biological Process: 2 (Carbohydrate metabolic process, Glycolytic process) | ||
KEGG Pathway: 1 (Glycolysis / gluconeogenesis) | |||
Calcium cycling (1) | Molecular function: 1 (Ryanodine-sensitive calcium-release channel activity) | ||
Spongy ventricle | Compact ventricle | 0 | None |
Compact ventricle | Spongy ventricle | 0 | None |