Fig. 1

SWI/SNF-regulated genes in adults. a A temperature-sensitive allele, swsn-1(os22ts), was used to demonstrate that SWI/SNF complexes are required in adult tissues for AFT [10]. Diagram (top) shows the temperature shift regimen and table (bottom) summarizes alcohol response behaviors from this experiment. b Principal component analysis with gene expression plotted relative to the first two principal components (PC1 and PC2). Wild type and swsn-1(os22ts) replicates are most similar to replicates of the same genotype. c Volcano plot shows genes that are up-regulated (red) and down-regulated (blue) in swsn-1(os22ts) mutants. Dashed lines indicate the FDR and fold change cutoffs (FDR ≤ 0.05 and fold change ≥1)