|
CpG name in HM450K array
|
PyroAssay name
|
Illumina infinium human methylation 450BEAD chip array
|
Pyrosequencing technical validation
|
|---|
|
beta_mean_CEU
|
beta_mean_CHB
|
CEU.beta_mean -CHB.beta_mean
|
q- value
|
CEU.mean
|
CHB.mean
|
CEU.mean -CHB.mean
|
p-value_beta
|
|---|
|
(n = 18)
|
(n = 18)
|
(n = 10)
|
(n = 10)
|
|---|
|
cg24861686
|
1_CpG1a
|
0.841
|
0.697
|
0.143
|
0.0000
|
0.813
|
0.591
|
0.222
|
0.0000
|
|
cg03140118
|
2_CpG1a
|
0.176
|
0.503
|
−0.327
|
0.0010
|
0.131
|
0.518
|
−0.387
|
0.0003
|
|
3_CpG1
|
–
|
–
|
–
|
–
|
0.410
|
0.150
|
0.259
|
0.0056
|
|
3_CpG2
|
–
|
–
|
–
|
–
|
0.289
|
0.087
|
0.202
|
0.0048
|
|
cg00862290
|
3_CpG3a
|
0.466
|
0.161
|
0.305
|
0.0080
|
–
|
–
|
–
|
–
|
|
cg07904028
|
4_CpG1a
|
0.515
|
0.714
|
−0.199
|
0.0145
|
–
|
–
|
–
|
–
|
|
cg08979191
|
5_CpG1a
|
0.779
|
0.520
|
0.258
|
0.0185
|
0.782
|
0.544
|
0.238
|
0.0117
|
|
5_CpG2
|
–
|
–
|
–
|
–
|
0.609
|
0.400
|
0.209
|
0.1174
|
|
5_CpG3
|
–
|
–
|
–
|
–
|
0.599
|
0.418
|
0.181
|
0.1942
|
|
6_CpG1
|
–
|
–
|
–
|
–
|
0.067
|
0.186
|
−0.119
|
0.0106
|
|
cg04036182
|
6_CpG2a
|
0.271
|
0.486
|
−0.215
|
0.0201
|
0.112
|
0.470
|
−0.358
|
0.0000
|
|
cg26367031
|
7_CpG1a
|
0.539
|
0.170
|
0.369
|
0.0215
|
–
|
–
|
–
|
–
|
|
cg18136963
|
8_CpG1
|
–
|
–
|
–
|
–
|
0.520
|
0.179
|
0.341
|
0.0019
|
|
8_CpG2a
|
0.514
|
0.162
|
0.352
|
0.0355
|
0.498
|
0.174
|
0.324
|
0.0097
|
|
8_CpG3
|
–
|
–
|
–
|
–
|
0.423
|
0.179
|
0.243
|
0.0180
|
|
cg07207043
|
9_CpG1a
|
0.625
|
0.820
|
−0.195
|
0.0345
|
0.529
|
0.813
|
−0.283
|
0.0023
|
|
9_CpG2
|
–
|
–
|
–
|
–
|
0.422
|
0.726
|
−0.304
|
0.0007
|
|
9_CpG3
|
–
|
–
|
–
|
–
|
0.480
|
0.814
|
−0.335
|
0.0004
|
|
10_CpG1
|
–
|
–
|
–
|
–
|
0.258
|
0.531
|
−0.272
|
0.0000
|
|
cg23669876
|
10_CpG2a
|
0.368
|
0.728
|
−0.360
| |
0.290
|
0.590
|
−0.299
|
0.0000
|
- HM450K array results are available only for HM450K-based candidate pop-CpGs (marked with a). For cg00862290, which corresponds to the third CpG locus in PyroAssay 3, no reliable pyrosequencing data was obtained. Assays 4 (cg07904028) and 7 (cg26367031) did not pass technical evaluation step
