Fig. 3

Reciprocal best hits found by all programs with bacterial proteomes. The proportion of RBH obtained with the fast programs is very similar to those obtained with blastp when genomes are very similar to each other (high Genomic Similarity Scores, GSS). As GSS decreases, the proportion falls. Both diamond and mmseqs showed improved proportions at low GSS compared to lastal. Close to 70% of the RBH detected are shared by all programs. Both diamond and mmseqs share the most RBH with blastp