Fig. 3

Heatmap of log2FC values with hierarchical clustering of genes based on V + F contrast uniquely differentially expressed genes (DEG) in the fetal placenta, thymus, or identified as DEG in both placenta and thymus. A) uniquely DEG genes in the placenta of V + F. B) DEG that were identified in both placenta and thymus of V + F. C) uniquely DEG in the thymus of V + F. The log2FC for each group was calculated in contrast to control (CTRL); 1. uninfected (UNINF), 2. placenta only with viable (PLCO-VIA), 3. PLCO with meconium staining (PLCO-MEC), 4. low viral load with VIA (LVL-VIA), 5. LVL-MEC, 6. high viral load VIA (HVL-VIA) and 7. HVL-MEC. 8. V + F calculated as (LVL-VIA, LVL-MEC, HVL-VIA, and HVL-MEC) contrasted to V - F (UNINF, PLCO-VIA, and PLCO-MEC). 9. MEC + F calculated as (PLCO-MEC, LVL-MEC, and HVL-MEC) contrasted to MEC - F (UNINF, PLCO-VIA, LVL-VIA, and HVL-VIA). The color corresponds to a gradient of the log2FC values ranging from downregulated in blue to upregulated in red