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Table 1 Summary of morphometrics and PRRSV viral load by fetal resilience groups

From: Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infection

 

Group

Classification

N

Placental viral load

Serum viral load

Thymus viral load

Fetal weight (g)

Crown rump length (cm)

Brain/ liver ratio

Placenta

CTRL

NA

15

ND

0 (0)

ND

757.7 (160.9)

27.2 (2.6)

1.4 (0.3)

UNINF

R

16

0 (0)

0 (0)

0 (0)

753.2 (251.4)

26.8 (3.6)

1.3 (0.4)

PLCO-VIA

R

12

5.3 (1.5)

0 (0)

0 (0)

751.5 (292.0)

26.8 (3.8)

1.5 (0.5)

PLCO-MEC

R

4

5.6 (2.7)

0 (0)

0 (0)

868.2 (228.6)

28.8 (2.7)

1.3 (0.4)

LVL-VIA

T

7

6.3 (1.45)

6.1 (1.1)

3.1 (0.5)

865.9 (200.1)

28.4 (3.1)

1.2 (0.3)

LVL-MEC

S

6

7.4 (0.9)

7.1 (0.9)

3.1 (0.9)

798.0 (145.8)

27.4 (2.8)

1.4 (0.6)

HVL-VIA

T

14

7.1 (1.1)

7.2 (0.8)

5.5 (0.6)

801.8 (257.8)

27.4 (2.8)

1.3 (0.4)

HVL-MEC

S

12

7.3 (0.6)

8.2 (0.8)

6.1 (0.6)

732.0 (143.3)

25.5 (1.6)

0.8 (0.3)

Thymus

CTRL

NA

14

ND

0 (0)

ND

748.8 (163.9)

27.1 (2.7)

1.4 (0.3)

UNINF

R

15

0 (0)

0 (0)

0 (0)

752.5 (260.2)

26.8 (3.7)

1.3 (0.5)

PLCO-VIA

R

15

5.4 (1.5)

0 (0.01)

0 (0)

734.1 (274.6)

26.7 (3.6)

1.5 (0.4)

PLCO-MEC

R

5

5.4 (2.4)

0 (0)

0 (0)

894.0 (206.2)

29.0 (2.4)

1.2 (0.4)

LVL-VIA

T

8

6.3 (1.4)

6.4 (1.2)

3.1 (0.5)

839.6 (199.7)

28.1 (3.0)

1.3 (0.3)

LVL-MEC

S

4

7.1 (1.0)

7.1 (1.1)

3.2 (0.9)

795.0 (173.4)

27.2 (2.8)

1.5 (0.8)

HVL-VIA

T

15

7.2 (1.2)

7.2 (0.8)

5.6 (0.6)

789.1 (253.2)

27.2 (2.8)

1.4 (0.4)

HVL-MEC

S

14

7.2 (0.6)

8.1 (0.8)

6.0 (0.7)

748.5 (127.3)

26.1 (1.7)

0.9 (0.3)

  1. Fetal phenotypes for groups based on PRRSV viral load as determined by quantitative PCR on fetal placenta, serum and thymus, in the form of group average in log10 copies/μL. Numbers for phenotypic measurements are displayed as the mean and standard error in parentheses. Further subdivision of fetuses was made based on preservation status at the time of sample collection with only fetuses classified as either viable (VIA) and meconium stained (MEC) used in the present work. Group control (CTRL) was mock infected, gilt infected but no virus detected in the fetus (UNINF), virus detected in the placenta only with viable (PLCO-VIA) or meconium-stained fetus (PLCO-MEC), low viral load in the fetus with viable (LVL-VIA) or meconium-stained fetus (LVL-MEC), and high viral load in the fetus with viable (HVL-VIA) or meconium-stained fetus (HVL-MEC). Classifications; NA (not applicable as not challenged), resilient (R), tolerant (T), susceptible (S)