Fig. 8

Predicted protein modeling of P4HB-021. (A-B) Protein domain organization of PDIA1 with indication of the four domains: a, b, b’, a’. (C-D) P4HB-021 splice variant shows a different conformation, particularly in the b domain, as compared to PDIA1. The model was predicted using the UniProt sequence and the SWISS Model (https://swissmodel.expasy.org). The absence of a 44-residue stretch at the transition between a and b domains associates with a predicted unstructured architecture, which might confer additional mobility in a way analogous to that provided by the x-linker between the b’ and a’ domains