Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array

Table 1 Description of the peripheral whole-blood-derived DNAm data on the EPIC platform

Cohort	Tissue type	Platform	GEO submitter	N	Normalization Method^a	Probe exclusion Criteria^b	Age range (years)
ABEC
Training data
MoBa-START	Peripheral whole blood	EPIC	–	1592	BMIQ	SC, CH, DP, SNP	19–59
Test data
MoBa-START	Peripheral whole blood	EPIC	–	424	BMIQ	SC, CH, DP, SNP	20–58
eABEC
Training data
MoBa-START	Peripheral whole blood	EPIC	–	1592	BMIQ	SC, CH, DP, SNP	19–59
GSE116339	Peripheral whole blood	EPIC	Curtis et al. [25]	635	Noob	SC	23–88
Test data
MoBa-START	Peripheral whole blood	EPIC	–	424	BMIQ	SC, CH, DP, SNP	20–58
GSE111165	Peripheral whole blood	EPIC	Shinozaki et al. [26]	15	Noob	SC	24–61
GSE115278	Peripheral whole blood	EPIC	Arpon et al. [27]	108	Noob	SC	19–66
Other test data
EPIPREG	Peripheral whole blood	EPIC	–	470	FunNorm	SC, CH, DP, SNP	19–42
GSE132203	Peripheral whole blood	EPIC	Kilaru et al. [28]	795	Noob	SC	18–76

^a Pre-processing method for quantifying DNAm levels in the range of 0 to 1
Noob Normal-exponential out-of-band [29]
BMIQ Beta-mixture quantile dilation [30]
FunNorm Functional normalization [31]
^b Probe exclusion criteria
SC Sex chromosome, CH cross-hybridizing, DP detection P-value < 0.01 and SNP single-nucleotide polymorphism

ISSN: 1471-2164