Fig. 1

Web interface of the circVAR database. In this version, we focused on single nucleotide variations and small insertions and deletions (INDELs). The page implemented data downloading, browsing and searching. For each circRNA in the database, the gene information is shown on the top right. In total, we integrated 295,526 circRNAs based on the GRCH 37 coordinates from circBase, circNet, and circRNAdb. By mapping to GRCH 38 coordinates, we identified 295,073 circRNAs. The basic information for each circRNA includes the circRNA ID in our database, data source, genomic locations for both GRCH 37 and GRCH 38, mapped genes and pre-computed genetic variants from GWASCatalog, ClinVAR, COSMIC, and the 1000 Genomes Project. Due to the huge volume of data, we provided bulk downloading for all pre-computed genetic variants from the four genetic variant databases