From: jouvence, a new human snoRNA involved in the control of cell proliferation
Gene_id | Fold Change | padj | Gene Name | Description |
A) HCT116-jou-knockdown (siRNA) (Up-regulated genes) | ||||
ENSG00000100867 | 12,26 | 1,51E-96 | DHRS2 | dehydrogenase/reductase (SDR) |
ENSG00000151012 | 16,74 | 2,25E-72 | SLC7A11 | solute carrier family 7 |
ENSG00000164171 | 6,97 | 6,83E-72 | ITGA2 | integrin, alpha 2 (CD49B) |
ENSG00000070669 | 5,81 | 1,65E-70 | ASNS | asparagine synthetase |
ENSG00000166750 | 6,68 | 1,62E-64 | SLFN5 | schlafen family member 5 |
ENSG00000101311 | 6,26 | 2,36E-64 | FERMT1 | fermitin family member 1 |
ENSG00000205730 | 7,02 | 4,60E-63 | ITPRIPL2 | inositol 1,4,5-trisphosphate recep. |
ENSG00000149948 | 4,82 | 1,58E-54 | HMGA2 | high mobility group AT-hook 2 |
ENSG00000101188 | 4,75 | 1,68E-51 | NTSR1 | neurotensin receptor (high aff.) |
ENSG00000179918 | 4,76 | 2,44E-49 | SEPHS2 | selenophosphate synthetase 2 |
ENSG00000179886 | 9,29 | 3,26E-49 | TIGD5 | tigger transposable element der.5 |
ENSG00000174564 | 19,57 | 4,95E-48 | IL20RB | interleukin 20 receptor beta |
ENSG00000225614 | 10,65 | 9,66E-46 | ZNF469 | zinc finger protein 469 |
ENSG00000139178 | 6,86 | 9,43E-44 | C1RL | complement component 1, |
ENSG00000185561 | 10,75 | 1,47E-43 | TLCD2 | TLC domain containing 2 |
ENSG00000176678 | 8,90 | 6,09E-43 | FOXL1 | forkhead box L1 |
ENSG00000265688 | 10,58 | 2,37E-41 | MAFG-AS1 | MAFG antisense RNA 1 |
ENSG00000196922 | 15,54 | 3,01E-41 | ZNF252P | zinc finger protein 252 pseudoge. |
ENSG00000163216 | 27,76 | 4,66E-40 | SPRR2D | small proline-rich protein 2D |
B) HCT116-jou-Knockdown (siRNA) (Down-regulated genes) | ||||
ENSG00000142871 | 0,19 | 1,84E-60 | CYR61 | cysteine-rich, angiogenic inducer |
ENSG00000186480 | 0,07 | 6,02E-59 | INSIG1 | insulin induced gene 1 |
ENSG00000079459 | 0,20 | 9,36E-50 | FDFT1 | farnesyl-diphosphate farnesyltr.1 |
ENSG00000145632 | 0,24 | 4,46E-49 | PLK2 | polo-like kinase 2 |
ENSG00000114019 | 0,15 | 3,07E-48 | AMOTL2 | angiomotin like 2] |
ENSG00000198911 | 0,26 | 4,69E-44 | SREBF2 | sterol regul. Element bind. TF 2 |
ENSG00000113161 | 0,26 | 6,68E-43 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA red |
ENSG00000011426 | 0,26 | 9,52E-42 | ANLN | anillin, actin binding protein |
ENSG00000169991 | 0,25 | 1,49E-40 | IFFO2 | intermediate filament family orphan 2 |
ENSG00000115963 | 0,23 | 1,29E-38 | RND3 | Rho family GTPase 3 |
ENSG00000158164 | 0,17 | 2,48E-38 | TMSB15A | thymosin beta 15a |
ENSG00000099860 | 0,26 | 8,21E-37 | GADD45B | growth arrest and DNA-damage |
ENSG00000130164 | 0,20 | 2,01E-36 | LDLR | low density lipoprotein receptor |
ENSG00000052802 | 0,14 | 1,79E-35 | MSMO1 | methylsterol monooxygenase 1 |
ENSG00000067064 | 0,27 | 3,24E-35 | IDI1 | isopentenyl-diphosphate del iso 1 |
ENSG00000162772 | 0,29 | 5,52E-35 | ATF3 | activating transcription factor 3 |
ENSG00000123975 | 0,30 | 1,56E-34 | CKS2 | CDC28 protein kinase regul.sub2 |
ENSG00000185022 | 0,30 | 1,44E-33 | MAFF | v-maf musculoaponeurotic fibros. |
ENSG00000147642 | 0,22 | 1,49E-33 | SYBU | syntabulin (syntaxin-interacting) |
C) HCT116-jou-Knockdown (siRNA) (KEGG enrichment pathways) | ||||
#Term (KEGG pathway) | ID | Input number | Background number | P-Value-corr |
Metabolic pathways | hsa01100 | 451 | 1243 | 3,20E-50 |
Ribosome | hsa03010 | 99 | 138 | 5,66E-26 |
Spliceosome | hsa03040 | 90 | 134 | 2,78E-22 |
Protein processing in endoplasmic reticulum | hsa04141 | 91 | 166 | 3,31E-18 |
Cell cycle | hsa04110 | 72 | 124 | 2,03E-15 |
Pathways in cancer | hsa05200 | 141 | 397 | 6,98E-15 |
Huntington’s disease | hsa05016 | 90 | 193 | 7,65E-15 |
Endocytosis | hsa04144 | 105 | 260 | 5,18E-14 |
Alzheimer’s disease | hsa05010 | 80 | 168 | 1,10E-13 |
RNA transport | hsa03013 | 81 | 172 | 1,10E-13 |
Ubiquitin mediated proteolysis | hsa04120 | 69 | 137 | 8,81E-13 |
Epstein-Barr virus infection | hsa05169 | 80 | 204 | 2,41E-10 |
Oocyte meiosis | hsa04114 | 59 | 123 | 2,41E-10 |
Parkinson’s disease | hsa05012 | 64 | 142 | 2,51E-10 |
Apoptosis | hsa04210 | 63 | 140 | 3,55E-10 |
Oxidative phosphorylation | hsa00190 | 61 | 133 | 3,75E-10 |
Carbon metabolism | hsa01200 | 55 | 113 | 5,90E-10 |
HTLV-I infection | hsa05166 | 91 | 259 | 8,16E-10 |
MAPK signaling pathway | hsa04010 | 90 | 255 | 8,16E-10 |