Table 2 Short list of the main genes deregulated in knockdown jouvence HCT116 cells revealed by RNA-Seq

Gene_id

Fold Change

padj

Gene Name

Description

 ENSG00000100867

12,26

1,51E-96

DHRS2

dehydrogenase/reductase (SDR)

 ENSG00000151012

16,74

2,25E-72

SLC7A11

solute carrier family 7

 ENSG00000164171

6,97

6,83E-72

ITGA2

integrin, alpha 2 (CD49B)

 ENSG00000070669

5,81

1,65E-70

ASNS

asparagine synthetase

 ENSG00000166750

6,68

1,62E-64

SLFN5

schlafen family member 5

 ENSG00000101311

6,26

2,36E-64

FERMT1

fermitin family member 1

 ENSG00000205730

7,02

4,60E-63

ITPRIPL2

inositol 1,4,5-trisphosphate recep.

 ENSG00000149948

4,82

1,58E-54

HMGA2

high mobility group AT-hook 2

 ENSG00000101188

4,75

1,68E-51

NTSR1

neurotensin receptor (high aff.)

 ENSG00000179918

4,76

2,44E-49

SEPHS2

selenophosphate synthetase 2

 ENSG00000179886

9,29

3,26E-49

TIGD5

tigger transposable element der.5

 ENSG00000174564

19,57

4,95E-48

IL20RB

interleukin 20 receptor beta

 ENSG00000225614

10,65

9,66E-46

ZNF469

zinc finger protein 469

 ENSG00000139178

6,86

9,43E-44

C1RL

complement component 1,

 ENSG00000185561

10,75

1,47E-43

TLCD2

TLC domain containing 2

 ENSG00000176678

8,90

6,09E-43

FOXL1

forkhead box L1

 ENSG00000265688

10,58

2,37E-41

MAFG-AS1

MAFG antisense RNA 1

 ENSG00000196922

15,54

3,01E-41

ZNF252P

zinc finger protein 252 pseudoge.

 ENSG00000163216

27,76

4,66E-40

SPRR2D

small proline-rich protein 2D

 ENSG00000142871

0,19

1,84E-60

CYR61

cysteine-rich, angiogenic inducer

 ENSG00000186480

0,07

6,02E-59

INSIG1

insulin induced gene 1

 ENSG00000079459

0,20

9,36E-50

FDFT1

farnesyl-diphosphate farnesyltr.1

 ENSG00000145632

0,24

4,46E-49

PLK2

polo-like kinase 2

 ENSG00000114019

0,15

3,07E-48

AMOTL2

angiomotin like 2]

 ENSG00000198911

0,26

4,69E-44

SREBF2

sterol regul. Element bind. TF 2

 ENSG00000113161

0,26

6,68E-43

HMGCR

3-hydroxy-3-methylglutaryl-CoA red

 ENSG00000011426

0,26

9,52E-42

ANLN

anillin, actin binding protein

 ENSG00000169991

0,25

1,49E-40

IFFO2

intermediate filament family orphan 2

 ENSG00000115963

0,23

1,29E-38

RND3

Rho family GTPase 3

 ENSG00000158164

0,17

2,48E-38

TMSB15A

thymosin beta 15a

 ENSG00000099860

0,26

8,21E-37

GADD45B

growth arrest and DNA-damage

 ENSG00000130164

0,20

2,01E-36

LDLR

low density lipoprotein receptor

 ENSG00000052802

0,14

1,79E-35

MSMO1

methylsterol monooxygenase 1

 ENSG00000067064

0,27

3,24E-35

IDI1

isopentenyl-diphosphate del iso 1

 ENSG00000162772

0,29

5,52E-35

ATF3

activating transcription factor 3

 ENSG00000123975

0,30

1,56E-34

CKS2

CDC28 protein kinase regul.sub2

 ENSG00000185022

0,30

1,44E-33

MAFF

v-maf musculoaponeurotic fibros.

 ENSG00000147642

0,22

1,49E-33

SYBU

syntabulin (syntaxin-interacting)

#Term (KEGG pathway)

ID

Input number

Background number

P-Value-corr

Metabolic pathways

hsa01100

451

1243

3,20E-50

Ribosome

hsa03010

99

138

5,66E-26

Spliceosome

hsa03040

90

134

2,78E-22

Protein processing in endoplasmic reticulum

hsa04141

91

166

3,31E-18

Cell cycle

hsa04110

72

124

2,03E-15

Pathways in cancer

hsa05200

141

397

6,98E-15

Huntington’s disease

hsa05016

90

193

7,65E-15

Endocytosis

hsa04144

105

260

5,18E-14

Alzheimer’s disease

hsa05010

80

168

1,10E-13

RNA transport

hsa03013

81

172

1,10E-13

Ubiquitin mediated proteolysis

hsa04120

69

137

8,81E-13

Epstein-Barr virus infection

hsa05169

80

204

2,41E-10

Oocyte meiosis

hsa04114

59

123

2,41E-10

Parkinson’s disease

hsa05012

64

142

2,51E-10

Apoptosis

hsa04210

63

140

3,55E-10

Oxidative phosphorylation

hsa00190

61

133

3,75E-10

Carbon metabolism

hsa01200

55

113

5,90E-10

HTLV-I infection

hsa05166

91

259

8,16E-10

MAPK signaling pathway

hsa04010

90

255

8,16E-10