Fig. 4
From: intePareto: an R package for integrative analyses of RNA-Seq and ChIP-Seq data
Comparison of intePareto with a model-based clustering approach and analysis of RNA-Seq alone. (a-d) In each of the four panels, the first point from the left on the red line marks the number of genes (x-axis) in the first two (Since there are only 14 genes in the first Pareto front shown in Fig. 3b) Pareto fronts together with the enrichment score (y-axis) of the respective GO term in that Pareto front. Accordingly, the second point refers to the genes in the first three Pareto fronts, etc. Assume that the first i Pareto fronts comprise a total ni genes, then the corresponding point on the black line takes the first ni genes, ranked by q-value obtained from the differential gene expression analysis based on RNA-Seq data alone. Note that the red line from the intePareto analysis always lies above the black line, indicating a stronger enrichment of the relevant GO terms in the integrated data compared to RNA-Seq data alone. The blue triangles mark the corresponding values of the existing integrative analysis method