Fig. 2

Full Network of proteins in and around the central platelet signaling cascade. The human and mouse networks were combined. The differences in both network topologies are shown in color code. The border paint marks expression values (blue for high expression in human; red for high expression in mouse; grey for no considerable expression differences). The node paint marks proteins that occur only in human platelet network (blue), only in human (blue rectangle; non-ortholog proteins), only in murine platelet network (red), only in mouse (red rectangle; non-ortholog proteins), or in both (white). The grey fill color of nodes indicates proteins that are not expressed in platelets in both species, or second messenger (e.g. Calcium, ATP, ADP). The node size increases with high expression differences. Further, edge color indicates interactions in both species (grey), in human (blue), in mouse (red) and in the central cascade (dark grey). High binders above 90% percentile where excluded. Abbreviations in the figure are the Entrez gene symbols and the full names are given for all proteins in Supplemental Table 1. Supplemental Fig. 5 is a separate jpeg file and a high-resolution version of Fig. 2. It allows to inspect better individual networks around different proteins, and the corresponding protein and gene expression differences between species