CAPRIB: a user-friendly tool to study amino acid changes and selection for the exploration of intra-genus evolution

Table 1 Operations available in CAPRIB

Operation	Definition	Set^a
I vs D	Identical amino acids in group A that changed to a different amino acid in group B	I_A ∩ D_B
IS vs D	Identical or similar amino acids in group A that changed to a different amino acid in group B	(I_A ∪ S_A) ∩ D_B
I vs S	Identical amino acids in group A that changed to a similar amino acid in group B	I_A ∩ S_B
GapIn	Gaps conserved in group A	N_A ∩ (S_B ∪ D_A)
GapOut	Gaps conserved in group B	(I_A ∪ S_A∪ D_A) ∩ O_B
Stop codon	Amino acids in group A replaced by a stop codon in group B	(I_A ∪ S_A∪ D_A) ∩ P_B

^asets of amino acid positions that are identical (I), similar (S), different (D), starting position of a gap in the reference organism (N), starting position of a gap in the compared organism (O) and the position of a stop codon (P)

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