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Table 6 Case 1 p-value rankings for Control 2 Animal compared to Control 1 Animal

From: Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands

     

Degree of Experimental Methylation Level Higher Than Control

Chromosome

CpG Island Start Location

CpG Island End Location

p-value

CpG Count

1–20% Proportion

1–20%

21–40%

41–60%

61–80%

81–100%

11

6,006,144

6,007,748

4.011E-20

27

0.000

0

1

4

14

8

4

134,159,558

134,164,691

5.662E-13

28

0.179

5

14

7

2

0

8

85,129,693

85,132,058

2.147E-09

10

0.000

0

7

3

0

0

8

10,978,436

10,978,759

2.607E-09

12

0.167

2

10

0

0

0

15

93,908,948

93,909,153

8.615E-08

10

0.000

0

9

1

0

0

4

146,941,454

146,942,785

2.027E-07

79

0.321

18

25

13

0

0

5

147,029,103

147,029,460

2.538E-07

15

0.467

7

7

1

0

0

15

38,118,394

38,118,655

3.010E-07

10

0.000

0

9

1

0

0

5

129,918,271

129,918,590

3.579E-07

14

0.286

4

5

5

0

0

3

69,393,711

69,394,087

5.160E-07

13

0.231

3

10

0

0

0

  1. The p-value represents the upper-tail p-value for the hypothesis test of higher methylation in the experimental mouse than the control mouse. The CG count includes the total number of CGs in the CpG island. The proportion and category counts only refer to the number of CGs where the experimental CG methylation level is higher than the control CG methylation level