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Table 6 Case 1 p-value rankings for Control 2 Animal compared to Control 1 Animal

From: Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands

      Degree of Experimental Methylation Level Higher Than Control
Chromosome CpG Island Start Location CpG Island End Location p-value CpG Count 1–20% Proportion 1–20% 21–40% 41–60% 61–80% 81–100%
11 6,006,144 6,007,748 4.011E-20 27 0.000 0 1 4 14 8
4 134,159,558 134,164,691 5.662E-13 28 0.179 5 14 7 2 0
8 85,129,693 85,132,058 2.147E-09 10 0.000 0 7 3 0 0
8 10,978,436 10,978,759 2.607E-09 12 0.167 2 10 0 0 0
15 93,908,948 93,909,153 8.615E-08 10 0.000 0 9 1 0 0
4 146,941,454 146,942,785 2.027E-07 79 0.321 18 25 13 0 0
5 147,029,103 147,029,460 2.538E-07 15 0.467 7 7 1 0 0
15 38,118,394 38,118,655 3.010E-07 10 0.000 0 9 1 0 0
5 129,918,271 129,918,590 3.579E-07 14 0.286 4 5 5 0 0
3 69,393,711 69,394,087 5.160E-07 13 0.231 3 10 0 0 0
  1. The p-value represents the upper-tail p-value for the hypothesis test of higher methylation in the experimental mouse than the control mouse. The CG count includes the total number of CGs in the CpG island. The proportion and category counts only refer to the number of CGs where the experimental CG methylation level is higher than the control CG methylation level