Fig. 4

Knockdown of different sRNAs leads to impaired regeneration. a Fraction of observed phenotypic defects during head regeneration per knockdown condition. PR = photoreceptors. Paired PR were considered irregular if PR size and/or distance to each other was beyond the range observed in control animals. Paired PR were also considered irregular if they lacked the surrounding white region. wt: wild type, b Significantly reduced eye size in each knockdown condition. Solid lines within boxes indicate median values, dotted lines within boxes indicate mean values. t-values are derived from a t-test for two independent means (2-tailed hypothesis) comparing scrambled versus sRNA in question. Scale bars: 250 μm. Corresponding p-values are < 0.0001 in each case