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Fig. 5 | BMC Genomics

Fig. 5

From: Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis

Fig. 5

a Hierarchical structure of randomized GRNs. The level 1 genes were excluded. b The histogram of degree (connectivity) of genes in the GRN, which showed power-law distribution. c The histogram of degree (connectivity) of genes in the random GRN, in which power-law distribution was lost. d Collaboration scores of genes at different levels. e Average numbers of interacting proteins of genes at different levels of the GRN hierarchy. f Fraction of cancer related genes at different levels. TFs at higher levels of the hierarchy were more associated with cancer (g) tau (cell type specificity) scores of genes at different levels. TFs at the bottom level of the hierarchy were cell type specifically expressed in hematopoiesis. h Fraction of essential genes at different levels. TFs at the bottom level of the hierarchy had a strong tendency to be essential genes. i Fraction of hematopoiesis related genes as annotated by GWAs at different levels. TFs at higher levels of the hierarchy were more associated with hematopoietic traits in GWAS studies

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BMC Genomics

ISSN: 1471-2164

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