Fig. 4

Inferred network. Network built with BRANE Cut from expression profiles of the differentially expressed genes. BRANE Cut selected 205 edges involving 161 genes. Node colors correspond to cluster labels: \(\mathcal {U}_{+}\) (red, genes highly and monotonically up-regulated on lactose), \(\mathcal {U}_{-}\) (dark red, genes slightly and monotonically up-regulated on lactose), \(\mathcal {U}_{\simeq }\) (orange, genes up-regulated and non-monotonically on lactose), \(\mathcal {D}_{-}\) (dark green, genes slightly and monotonically down-regulated on lactose) and \(\mathcal {D}_{+}\) (green, genes highly and monotonically down-regulated on lactose). Bigger nodes with bold frame correspond to genes coding for a transcription factor while smaller nodes with thin frame correspond to genes not identified to code for a transcription factor