Table 4 The top 10 FDR corrected genes identified by MGAS in 8 subcortical ROIs
NO. | Gene | PMGAS | Chr | SNP | PLAmygVol | PRAmygVol | PLHippVol | PRHippVol | PLAccumVol | PRAccumVol | PLPutamVol | PRPutamVol |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | APOE | 2.77E-08 | 19 | rs769449 | 3.98E-06 | 1.38E-04 | 5.77E-07 | 9.52E-09 | 1.58E+ 00 | 1.48E+ 00 | 2.11E+ 00 | 2.44E+ 00 |
2 | TOMM40 | 3.49E-08 | 19 | rs769449 | 3.98E-06 | 1.38E-04 | 5.77E-07 | 9.52E-09 | 1.58E+ 00 | 1.48E+ 00 | 2.11E+ 00 | 2.44E+ 00 |
3 | APOC1 | 1.18E-06 | 19 | rs4420638 | 3.09E-05 | 3.46E-05 | 7.70E-06 | 5.23E-07 | 6.99E-01 | 1.34E+ 00 | 3.06E+ 00 | 2.71E+ 00 |
4 | LAMA1 | 3.79E-05 | 18 | rs656734 | 2.62E-05 | 8.64E-07 | 3.11E-04 | 5.53E-04 | 5.64E+ 00 | 2.45E+ 00 | 4.27E+ 00 | 5.26E+ 00 |
5 | XYLB | 6.72E-05 | 3 | rs196376 | 1.80E-02 | 6.61E-04 | 8.64E-05 | 6.63E-06 | 2.06E-02 | 5.68E-01 | 9.22E-01 | 7.13E-02 |
6 | HSD17B7P2 | 8.40E-05 | 10 | rs12221164 | 3.42E+ 00 | 4.05E+ 00 | 5.92E+ 00 | 5.09E+ 00 | 1.16E-04 | 1.02E-01 | 7.86E+ 00 | 7.93E+ 00 |
7 | NPEPL1 | 8.63E-05 | 20 | rs2426778 | 5.96E-01 | 3.89E+ 00 | 7.38E-01 | 2.17E+ 00 | 7.32E+ 00 | 2.09E-02 | 2.13E-05 | 3.39E-03 |
8 | OR5B2 | 9.40E-05 | 11 | rs11229440 | 1.62E+ 00 | 8.20E-01 | 3.90E-01 | 1.05E+ 00 | 1.67E+ 00 | 8.30E-03 | 2.22E-04 | 9.52E-05 |
9 | MIR7160 | 1.10E-04 | 8 | rs6558595 | 8.22E-01 | 7.69E+ 00 | 3.07E-01 | 1.13E+ 00 | 8.50E-02 | 1.68E+ 00 | 3.49E-05 | 3.67E-04 |
10 | CYP24A1 | 1.20E-04 | 20 | rs3787555 | 2.10E-01 | 4.75E+ 00 | 3.64E+ 00 | 2.19E+ 00 | 7.80E+ 00 | 1.75E+ 00 | 1.71E-01 | 9.55E-01 |