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Table 2 Comparison of the results of all available systems and proposed search methods on the validation set. SEN Sensitivity, SPE Specificity, PPV Positive Predictive Value, ACC Accuracy, MCC Matthew’s Correlation Coefficient, Avg-AUC Average Area Under the Curve. (Accessed date: July 2017)

From: Conformational epitope matching and prediction based on protein surface spiral features

Prediction System SEN SPC PPV ACC F1 score MCC Avg-AUC Prediction Condition
CEKEG (2013) 0.528 0.786 0.292 0.775 0.370 0.236 0.657 Best Result from Top3 prediction
ElliPro (2008) 0.343 0.901 0.357 0.826 0.300 0.227 0.622 Best Result from Top3 prediction
CBTOPE (2010) 0.334 0.665 0.087 0.597 0.133 0.000 0.500 SVM threshold: 0.3 (default)
Epitopia (2009) 0.274 0.836 0.187 0.761 0.210 0.081 0.555 Immunogenicity Scale: 5
EPSVR (2010) 0.198 0.815 0.137 0.733 0.152 0.007 0.507 Epitope score > 80
Discotope2.0 (2012) 0.190 0.847 0.244 0.773 0.140 0.065 0.518 Threshold: −3.7 (default)
Search System TPR SPC PPV ACC F1 score MCC Avg-AUC Prediction Condition
CSS 0.120 0.978 0.132 0.890 0.123 0.028 0.549 Best Result from Top3 prediction
SVS 0.473 0.869 0.365 0.853 0.396 0.307 0.671 Best Result from Top3 prediction